Modulation of Inflammatory Response Improves Myocardial Infarct Healing in Rats / Sarapultsev A. P.,Chupakhin O. N.,Sarapultsev P. A.,Rantsev M. A.,Medvedeva S. U.,Sidorova L. P.,Abidov M. T.,Danilova I. G. // CURRENT PHARMACEUTICAL DESIGN. - 2014. - V. 20, l. 12. - P. 1980-1986.

ISSN/EISSN:

1381-6128 / 1873-4286

Type:

Article

Abstract:

It is reputed that the ideal therapeutic approaches to treatment of patients with acute coronary syndrome (ACS) and myocardium infarction (MI) should be aimed at the inflammation reaction triggers. This study investigated the effectiveness of the impact of L-17 compound of the group of 5- phenyl substituted-6H-1,3,4-thiadiazine-2-amines upon the course of experimental MI as compared to the impact of a preparation, officially registered in Russia as an immunomodulator, Tamerit, belonging to phthalhydrazid derivative substance. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections and biochemical analysis has been carried out at the 1st and 7th days of the experimental MI. The conducted investigations have shown that under the action of immunocorrectors the inflammation reaction character changes, exudative/destructive inflammation is replaced by a proliferativecellular one. Animals' blood biochemical analysis at the background of L-17 and Tamerit introduction has shown a decrease of aminotransferases and lactatedehydrogenases activity in blood as compared to the reference group of animals' indicators, which is evidently caused by epicardial injury of myocardium and lesser amount of the alternative cardiomyocytes. At the same time, no noticeable difference in biochemical characteristics in groups, having been treated to immunomodulators of different chemical composition was identified, which is the sign of the essential similarity of their impact. Thus, immunocorrectors of different chemical groups (Tamerit and compound L17) diminish the volume of initial myocardial infarction and accelerate the granulation processes in course of MI, and represent a new category of treatment agents.

Author keywords:

Inflammation; L-17 compound; myocardial infarction; Tamerit; thiadiazine-2 amines; sodium nucleinate ACUTE CORONARY SYNDROMES; NEUTROPHIL DEPLETION; INJURY; HEART; ISCHEMIA; SIZE; ANGIOGENESIS; REPERFUSION; MANAGEMENT; LEUKOCYTES

DOI:

нет данных

Web of Science ID:

ISI:000334312500007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	APR
Publisher	BENTHAM SCIENCE PUBL LTD
Address	EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
Language	English
EISSN	1873-4286
Keywords-Plus	ACUTE CORONARY SYNDROMES; NEUTROPHIL DEPLETION; INJURY; HEART; ISCHEMIA; SIZE; ANGIOGENESIS; REPERFUSION; MANAGEMENT; LEUKOCYTES
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Pharmacology \& Pharmacy
Author-Email	a.sarapultsev@gmail.com
ORCID-Numbers	Sarapultsev, Alexey/0000-0003-3101-9655
Funding-Acknowledgement	Special Research Grant of Interdisciplinary project of the Institute of Immunology and Physiology; Institute of Organic Synthesis, Ural Branch of RAS {[}12-M-34-2064]
Funding-Text	This study was supported by a Special Research Grant of Interdisciplinary project of the Institute of Immunology and Physiology and the Institute of Organic Synthesis, Ural Branch of RAS (12-M-34-2064).
Number-of-Cited-References	43
Usage-Count-Last-180-days	4
Usage-Count-Since-2013	25
Journal-ISO	Curr. Pharm. Design
Doc-Delivery-Number	AE9FY