SYNTHESIS AND ANTITUMOR ACTIVITY OF FLUORINATED DERIVATIVES OF {[}i,j]-ANNELATED QUINOLONES / Lipunova G. N.,Nosova E. V.,Sidorova L. P.,Charushin V. N. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2011. - V. 45, l. 4. - P. 208-210.

ISSN/EISSN:

0091-150X / нет данных

Type:

Article

Abstract:

Tri- and pentacyclic fluoroquinolones were synthesized by intramolecular cyclization of the corresponding 3-hydrazinopolyfluorobenzoylacrylates followed by substitution of fluorine atoms by amine residues. The antitumor activity of the resulting compounds was studied at the National Cancer Institute using cultures of 60 cell lines of nine groups, including leukemia, lung tumor, large intestine tumor, CNS tumor, melanoma, ovary tumor, renal tumor, prostate tumor, and breast tumor. Relationships between structure and antitumor activity were analyzed. In vivo experimental data from hollow fiber tests are presented for two derivatives.

Author keywords:

1,3,4-Thiadiazino{[}5,6,4-i,j]quinoline; benzimidazo{[}2 `,3 `:3,4]-1,2,4-triazino{[}5,6,1-i,j]quinoline; synthesis; antitumor activity FLUOROQUINOLONES

DOI:

нет данных

Web of Science ID:

ISI:000294718600004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	FLUOROQUINOLONES
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
Author-Email	emyly74@rambler.ru
Funding-Acknowledgement	State Contract {[}GK-02.740.11.0260]; Scientific Schools {[}NSh-65261.2010.3]
Funding-Text	This study was supported by State Contract GK-02.740.11.0260 and Scientific Schools grant No. NSh-65261.2010.3.
Number-of-Cited-References	7
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	2
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	817ZV