Three-component cyclization of hydroxylamino-substituted quinoline with reactive methylene compounds and formaldehyde: new method for the synthesis of 7-(isoxazolidin-2-yl)-6-fluoroquinolones / Mochulskaya NN,Sidorova LP,Charushin VN // RUSSIAN CHEMICAL BULLETIN. - 2002. - V. 51, l. 11. - P. 2106-2108.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

A one-step procedure was developed for the synthesis of new 6-fluoro-7-(isoxazolidin2-yl)-4-oxo-1,4-dihydroquinolines. The procedure is based on the 1,3-dipolar cycloaddition of the azomethine oxide and 1, 1-disubstituted alkenes, which are generated in situ from 6-fluoro-7-hydroxylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and CH-active compounds (dialkyl malonates, ethyl acetoacetate), respectively, in the presence of formaldehyde at 100-120 degreesC.

Author keywords:

fluoroquinolones; three-component cyclization; beta-dicarbonyl compounds; formaldehyde; 1,3-dipolar cycloaddition; 6-fluoro-7-(isoxazolidin-2-yl)-4-oxo-1,4-dihydroquinolones

DOI:

10.1023/A:1021680414417

Web of Science ID:

ISI:000180430300020

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	CONSULTANTS BUREAU
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Number-of-Cited-References	10
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	635ZP