A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones / Obydennov Dmitrii L.,Sidorova Ekaterina S.,Usachev Boris I.,Sosnovskikh Vyacheslav Ya. // TETRAHEDRON LETTERS. - 2013. - V. 54, l. 24. - P. 3085-3087.

ISSN/EISSN:

0040-4039 / нет данных

Type:

Article

Abstract:

Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at -20 degrees C for 2-21 days gave 5-amino-3-oxopent-4-enamides in 28-78\% yields, which were cyclized with DMF-DMA in toluene under ambient conditions to afford 4-pyridone-3-carboxamides in 31-70\% yields. (C) 2013 Elsevier Ltd. All rights reserved.

Author keywords:

2-Cyano-4-pyrones; 5-Amino-3-oxopent-4-enamides; 4-Pyridone-3-carboxamides; DMF-DMA; Cyclization ACID; 4-OXO-1,4-DIHYDROPYRIDINES; 2-PYRIDONES; DERIVATIVES; 4-PYRIDONES

DOI:

10.1016/j.tetlet.2013.03.132

Web of Science ID:

ISI:000319645100014

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN 12
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Keywords-Plus	ACID; 4-OXO-1,4-DIHYDROPYRIDINES; 2-PYRIDONES; DERIVATIVES; 4-PYRIDONES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	dobydennov@mail.ru
Funding-Acknowledgement	Ural Federal University
Funding-Text	This work was supported by the Ural Federal University (Program of Support of Young Scientists).
Number-of-Cited-References	15
Usage-Count-Since-2013	10
Journal-ISO	Tetrahedron Lett.
Doc-Delivery-Number	154AY