Synthesis of Novel 5,6-Dihydropyrrolo{[}2,1-a]isoquinolines via Grob Reaction between (E)-1,1,1-Trifluoro-3-nitro-2-butene and 3,4-Dihydroisoquinolines / Korotaev Vladislav Y.,Sosnovskikh Vyacheslav Y.,Barkov Alexey Y.,Slepukhin Pavel A.,Shklyaev Yurii V. // JOURNAL OF HETEROCYCLIC CHEMISTRY. - 2012. - V. 49, l. 4. - P. 856-860.

ISSN/EISSN:

0022-152X / нет данных

Type:

Article

Abstract:

Uncatalyzed cycloaddition of 3,4-dihydroisoquinolines to (E)-1,1,1-trifluoro-3-nitro-2-butene via Grob reaction provide a simple one-step route to the 5,6-dihydropyrrolo{[}2,1-a]isoquinolines, which represent the basic structural framework of the antitumor active alkaloid crispine.

Author keywords:

ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; 3-STEP SYNTHESIS; NITRO-OLEFINS; DERIVATIVES; (+/-)-CRISPINE-A; NITROALKENES; 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE; ALKALOIDS; PYRROLES

DOI:

10.1002/jhet.881

Web of Science ID:

ISI:000308586900023

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL
Publisher	WILEY-BLACKWELL
Address	111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Language	English
Keywords-Plus	ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; 3-STEP SYNTHESIS; NITRO-OLEFINS; DERIVATIVES; (+/-)-CRISPINE-A; NITROALKENES; 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE; ALKALOIDS; PYRROLES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	Vyacheslav.Sosnovskikh@usu.ru
ResearcherID-Numbers	Korotaev, Vladislav/L-2692-2016
ORCID-Numbers	Korotaev, Vladislav/0000-0002-7492-5116
Funding-Acknowledgement	RFBR {[}10-03-00138]; Presidium program of the RAS N 21
Funding-Text	This work was financially supported by the RFBR (grant 10-03-00138) and the Presidium program of the RAS N 21.
Number-of-Cited-References	46
Usage-Count-Since-2013	9
Journal-ISO	J. Heterocycl. Chem.
Doc-Delivery-Number	003CX