3-(Dichloroacetyl)chromone; A New Building Block for the Synthesis of Formylated Purine Isosteres: Design and Synthesis of Fused alpha-(Formyl)pyridines / Iaroshenko Viktor O.,Mkrtchyan Satenik,Ghazaryan Gagik,Hakobyan Ani,Maalik Aneela,Supe Linda,Villinger Alexander,Tolmachev Andrei,Ostrovskyi Dmytro,Sosnovskikh Vyacheslav Ya.,Ghochikyan Tariel V.,Langer Peter // SYNTHESIS-STUTTGART. - 2011. - V. , l. 3. - P. 469-479.

ISSN/EISSN:

0039-7881 / нет данных

Type:

Article

Abstract:

The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one and dichloroacetyl chloride is described. The reaction of electron-rich aminoheterocycles with 3-(dichloroacetyl) chromone provides a set of diverse fused pyridines bearing the CHCl2-substituent at the a-position of the pyridine core. Subsequent hydrolysis leads to the formation of annulated alpha-(formyl)pyridines.

Author keywords:

3-(dichloroacetyl)chromone; 4H-1-benzopyran-4-one; heterocyclic amines; fused pyridines; annulation reactions NICOTINIC-ACID DERIVATIVES; PRIVILEGED STRUCTURES; 3-SUBSTITUTED CHROMONES; ADENOSINE-DEAMINASE; EFFICIENT SYNTHESIS; ACTIVE METHYLENE; DRUG DISCOVERY; INHIBITORS; 3-(POLYFLUOROACYL)CHROMONES; CHEMISTRY

DOI:

10.1055/s-0030-1258364

Web of Science ID:

ISI:000286508400018

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	FEB
Publisher	GEORG THIEME VERLAG KG
Address	RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Language	English
Keywords-Plus	NICOTINIC-ACID DERIVATIVES; PRIVILEGED STRUCTURES; 3-SUBSTITUTED CHROMONES; ADENOSINE-DEAMINASE; EFFICIENT SYNTHESIS; ACTIVE METHYLENE; DRUG DISCOVERY; INHIBITORS; 3-(POLYFLUOROACYL)CHROMONES; CHEMISTRY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	viktor.iaroshenko@uni-rostock.de yaroshenko@enamine.net
Number-of-Cited-References	65
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	6
Journal-ISO	Synthesis
Doc-Delivery-Number	710JR