3-Formylchromones, Acylpyruvates, and Chalcone as Valuable Substrates for the Syntheses of Fused Pyridines / Iaroshenko Viktor O.,Mkrtchyan Satenik,Volochnyuk Dmitriy M.,Langer Peter,Sosnovskikh Vyacheslav Ya.,Ostrovskyi Dmytro,Dudkin Sergii,Kotljarov Anton V.,Miliutina Mariia,Savych Iryna,Tolmachev Andrei A. // SYNTHESIS-STUTTGART. - 2010. - V. , l. 16. - P. 2749-2758.

ISSN/EISSN:

0039-7881 / нет данных

Type:

Article

Abstract:

The reaction of electron-rich aminoheterocycles with 1,3-CCC-dielectrophiles, such as 3-formylchromones, acylpyruvates, and chalcone, provided diversely fused pyridines. Starting from 5-amino-1-(2,3-O-isopropylidene-beta-D-ribofuranosyl)-1H-pyrazole, nucleosides containing a pyrazolo{[}3,4-b]pyridine fragment were obtained, which can be considered as adenosine deaminase (ADA) inhibitors.

Author keywords:

aminoheterocycles; 3-formylchromones; acylpyruvates; chalcone; fused pyridines; annulation reaction; nucleosides CHLOROTRIMETHYLSILANE-MEDIATED SYNTHESIS; EDITING ADENOSINE-DEAMINASE; NICOTINIC-ACID DERIVATIVES; INHIBITORS; QUINOLINES; ANALOGS; RNA; 3-(POLYFLUOROACYL)CHROMONES; DESIGN; ALPHA

DOI:

10.1055/s-0029-1218842

Web of Science ID:

ISI:000282105800009

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	AUG
Publisher	GEORG THIEME VERLAG KG
Address	RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Language	English
Keywords-Plus	CHLOROTRIMETHYLSILANE-MEDIATED SYNTHESIS; EDITING ADENOSINE-DEAMINASE; NICOTINIC-ACID DERIVATIVES; INHIBITORS; QUINOLINES; ANALOGS; RNA; 3-(POLYFLUOROACYL)CHROMONES; DESIGN; ALPHA
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	viktor.iaroshenko@uni-rostock.de vyacheslav.sosnovskikh@usu.ru
Number-of-Cited-References	43
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	5
Journal-ISO	Synthesis
Doc-Delivery-Number	653OZ