Facile Synthesis of Fluorinated Benzofuro- and Benzothieno{[}2,3-b]pyridines, alpha-Carbolines and Nucleosides Containing the alpha-Carboline Framework / Iaroshenko Viktor O.,Wang Yan,Zhang Biao,Volochnyuk Dmitriy,Sosnovskikh Vyacheslav Ya. // SYNTHESIS-STUTTGART. - 2009. - V. , l. 14. - P. 2393-2402.

ISSN/EISSN:

0039-7881 / нет данных

Type:

Article

Abstract:

Fluorinated benzofuro{[}2,3-b]pyridines, benzothieno{[}2,3-b] pyridines and 9H-pyrido{[}2,3-b]indoles (alpha-carbolines) were synthesized via regiospecific pyridine core annulation of a number of fluoro-containing 1,3-CCC-dielectrophiles to benzofuran-2-amine, benzothiophen-2-amine and 1H-indol-2-amine. Based on the 2,4-bis(trifluoromethyl)-9H-pyrido{[}2,3-b]indole thus synthesized, the preparative approach towards a set of nucleosides and nucleoside mimetics bearing the alpha-carboline framework was elaborated.

Author keywords:

pyridines; fluorine; annulation; functionalization; alpha-carbolines; nucleosides CARBOCYCLIC NUCLEOSIDES; NUCLEOTIDE BIOSYNTHESIS; PRACTICAL SYNTHESIS; ANTIVIRAL AGENTS; D-CYCLOPENTENONE; D-RIBOSE; INHIBITORS; ANALOGS; HERPESVIRUSES; DERIVATIVES

DOI:

10.1055/s-0029-1217396

Web of Science ID:

ISI:000268779100016

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUL 15
Publisher	GEORG THIEME VERLAG KG
Address	RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Language	English
Keywords-Plus	CARBOCYCLIC NUCLEOSIDES; NUCLEOTIDE BIOSYNTHESIS; PRACTICAL SYNTHESIS; ANTIVIRAL AGENTS; D-CYCLOPENTENONE; D-RIBOSE; INHIBITORS; ANALOGS; HERPESVIRUSES; DERIVATIVES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	yaroshenko@enamine.net
Number-of-Cited-References	35
Usage-Count-Since-2013	6
Journal-ISO	Synthesis
Doc-Delivery-Number	481AQ