New derivatives of 6-phenylcomanic acid / Usachev B. I.,Obydennov D. L.,Kodess M. I.,Roeschenthaler G. -V.,Sosnovskikh V. Ya. // RUSSIAN CHEMICAL BULLETIN. - 2009. - V. 58, l. 6. - P. 1248-1252.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2-carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpicolinic acid, converted further to its ethyl ester and hydrazide. The reaction of 6-phenylcomanic acid with phenylhydrazine gives rise to 3-(1,5-diphenyl-1H-pyrazol-3-yl)-2-(2-phenylhydrazono)propionic acid, which by the Fischer reaction was converted to 3-(1,5-diphenyl-1H-pyrazol-3-yl)-1H-indole-2-carboxylic acid.

Author keywords:

6-phenylcomanic acid and its derivatives; 4-hydroxy-6-phenylpicolinic acid and its derivatives; phenylhydrazine; Fischer indole synthesis ANTI-ALLERGIC AGENTS

DOI:

10.1007/s11172-009-0162-8

Web of Science ID:

ISI:000277098500021

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	ANTI-ALLERGIC AGENTS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	Boris.Usachev@mail.ru
Funding-Acknowledgement	Russian Foundation for Basic Research {[}06-03-04004-NNIO]; German Research Society {[}436 RUS 113/901/0-1]
Funding-Text	This work was financially supported by the Russian Foundation for Basic Research (Project No. 06-03-04004-NNIO) and German Research Society (Grant 436 RUS 113/901/0-1).
Number-of-Cited-References	11
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	4
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	588UB