Synthesis of 1-(2-polyfluoroacylaminophenyl)-3-polyfluoroalkylpropane-1,3-diones and 2-polyfluoroalkyl-4-quinolones / Sosnovskikh VY,Usachev BI,Sizov AY // RUSSIAN CHEMICAL BULLETIN. - 2002. - V. 51, l. 11. - P. 2109-2115.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

The condensation of 2-aminoacetophenone with (RCO2Et)-C-F (R-F = CF3, CF2H, CF2CF2H) in the presence of LiH in THF or (BuOK)-O-t in (BuOH)-O-t affords either 2-polyfluoroalkyl-4-quinolones or 1-(2-polyfluoroacylaminophenyl)-3-polyfluoroalkylpropane-1,3-diones, depending on the ratio of the initial reactants. The latter are hydrolyzed in an acidic medium to produce 2-polyfluoroalkyl-4-quinolones. N-Methyl-2-trifluoromethyl-4-quinolone was synthesized from 2-aminoacetophenone, CF3CO2Et, and MeI in the presence of (BuOK)-O-t.

Author keywords:

2-aminoacetophenone; ethyl polyfluorocarboxylates; condensation; 1-(2-polyfluoroacylaminophenyl)-3-polyfluoroalkylpropane-1,3-diones; 2-polyfluoroalkyl-4-quinolones; tautomerism BUILDING-BLOCK; CONVENIENT; TRIFLUOROACETYLATION

DOI:

10.1023/A:1021632531255

Web of Science ID:

ISI:000180430300021

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	CONSULTANTS BUREAU
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	BUILDING-BLOCK; CONVENIENT; TRIFLUOROACETYLATION
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Number-of-Cited-References	22
Usage-Count-Since-2013	4
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	635ZP