A simple and efficient synthesis of 2-methyl-2-trifluoromethylchroman-4-ones from 2-trifluoromethyl-4H-chromen-4-imines and malonic acid / Sosnovskikh VY,Usachev BI // SYNTHESIS-STUTTGART. - 2002. - V. , l. 16. - P. 2341-2343.

ISSN/EISSN:

0039-7881 / нет данных

Type:

Article

Abstract:

N-Benzyl-2-trifluoromethyl-4H-chromen-4-imines and malonic acid on heating in anhydrous dioxane afford 2-trifluoromethyl-2-methylchroman-4-ones in similar to60\% yield. 2-Methyl-2-trifluoromethyl-4-oxochromane-6-carbaidehyde and 2-methyl-2-trifluoromethyl-4-oxochromane-6-carboxylic acid, the fluorinated analogues of natural lactarochromal and the corresponding acid, were obtained by the oxidation of 2,6-climethyl-2-trifluoromethylchroman-4-one with K2S2O8.

Author keywords:

N-benzyl-2-trifluoromethyl-4H-chromen-4-imines; malonic acid; 2-methyl-2-trifluoromethylchroman-4-ones; oxidation; fluorinated analogues of natural compounds CONJUGATE ADDITION; CHROMONES; 2-POLYFLUOROALKYLCHROMONES; DERIVATIVES; REAGENTS

DOI:

10.1055/s-2002-35233

Web of Science ID:

ISI:000179393600004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	GEORG THIEME VERLAG KG
Address	RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Language	English
Keywords-Plus	CONJUGATE ADDITION; CHROMONES; 2-POLYFLUOROALKYLCHROMONES; DERIVATIVES; REAGENTS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	Vyacheslav.Sosnovskikh@usu.ru
Number-of-Cited-References	17
Usage-Count-Since-2013	1
Journal-ISO	Synthesis
Doc-Delivery-Number	618AB