Potentiometric Study of Antioxidant Activity: Development and Prospects / Ivanova A. V.,Gerasimova E. L.,Brainina Kh. Z. // CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY. - 2015. - V. 45, l. 4. - P. 311-322.

ISSN/EISSN:

1040-8347 / 1547-6510

Type:

Review

Abstract:

The increasing interest in the study of the antioxidant activity of different objects is caused by an unbalance between the formation of reactive oxygen species (ROS) and the performance of the antioxidant system in humans under certain conditions, which leads to oxidative stress and pathological states of the organism. This article presents a brief critical review of the methods that are used to measure integrated antioxidant activity (AOA). It is shown that the most promising methods for measuring AOA are electrochemical ones, particularly potentiometry, as it best fits the nature of the processes causing oxidative stress. The article gives the theoretical rational for requirements that an oxidizer of antioxidants (AO) should meet. The work presents the thermodynamic grounds for the use of an earlier proposed mediator system, kinetics of chemical reactions between AO and the mediator system. In order to confirm reliability and accuracy of the results, numerous correlation studies were conducted, aiming to compare the data obtained with the use the proposed method and independent analytical methods. The article presents the results of the potentiometric study of AOA for a variety of objects, including individual antioxidant -> nutritional supplements -> food -> blood and blood fractions.

Author keywords:

mediator system; antioxidant activity; food; potentiometry; blood CUPRAC METHOD; SCAVENGING ASSAY; CAPACITY ASSAYS; HUMAN SERUM; PLASMA; DPPH; CAPABILITY; FLAVONOIDS; FRAP

DOI:

10.1080/10408347.2014.910443

Web of Science ID:

ISI:000354873700003

Соавторы в МНС:

Другие поля

Поле	Значение
Month	OCT 2
Publisher	TAYLOR \& FRANCIS INC
Address	530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
Language	English
EISSN	1547-6510
Keywords-Plus	CUPRAC METHOD; SCAVENGING ASSAY; CAPACITY ASSAYS; HUMAN SERUM; PLASMA; DPPH; CAPABILITY; FLAVONOIDS; FRAP
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Analytical
Author-Email	baz@usue.ru
Funding-Acknowledgement	RFBR {[}13-08-96-050 r ural \_3]; Ministry of Education and Science of RF {[}1458, 4.1458.2014/k]; Act 211 Government of the Russian Federation {[}02.A03.21.0006]
Funding-Text	The authors express deep gratitude to the RFBR (Project \#13-08-96-050 r ural \_3), to the Ministry of Education and Science of RF (Project \#1458 in the framework of the assignment 4.1458.2014/k), and to the Act 211 Government of the Russian Federation no. 02.A03.21.0006 for financial support.
Number-of-Cited-References	40
Usage-Count-Last-180-days	8
Usage-Count-Since-2013	79
Journal-ISO	Crit. Rev. Anal. Chem.
Doc-Delivery-Number	CI6MM