Subchronic Systemic Toxicity and Bioaccumulation of Fe(3)O(4) Nano- and Microparticles Following Repeated Intraperitoneal Administration to Rats / Katsnelson Boris A.,Degtyareva Tamara D.,Minigalieva Ilzira I.,Privalova Larisa I.,Kuzmin Sergey V.,Yeremenko Olga S.,Kireyeva Ekaterina P.,Sutunkova Marina P.,Valamina Irene I.,Khodos Mark Y.,Kozitsina Alisa N.,Shur Vladimir Y.,Vazhenin Vladimir A.,Potapov Aleksandr P.,Morozova Maria V. // INTERNATIONAL JOURNAL OF TOXICOLOGY. - 2011. - V. 30, l. 1. -

ISSN/EISSN:

1091-5818 / нет данных

Type:

Article

Abstract:

Aqueous suspensions of 10 nm, 50 nm, or 1 mu m Fe(3)O(4) particles were injected intraperitoneally (ip) to rats at a dose of 500 mg/kg in 4 mL of sterile deionized water 3 times a week for 5 weeks. Following exposure, functional and biochemical indices and histopathological examinations of spleen and liver tissues of exposed rats were evaluated for signs of toxicity. The iron content of the blood was measured photometrically, and that of the liver and the spleen by atomic adsorption spectroscopy (AAS) and electron paramagnetic resonance (EPR) methods. It was found that, given equal mass doses, Fe(3)O(4) nanoparticles possess considerably higher systemic toxicity than microparticles, but within the nanometric range the relationship between particle size and resorptive toxicity is intricate and nonunique. The latter fact may be attributed to differences in different nanoparticles' toxicokinetics, which are controlled by both more or less substantial direct penetration of nanoparticles through biological barriers and their unequal solubility.

Author keywords:

nanoparticles; magnetite; subchronic toxicity IN-VIVO; GOLD NANOPARTICLES; BIODISTRIBUTION; NANOTOXICOLOGY; REACTIVITY; EXPOSURE; MICE

DOI:

10.1177/1091581810385149

Web of Science ID:

ISI:000288280200006

Соавторы в МНС:

Другие поля

Поле	Значение
Month	FEB
Publisher	SAGE PUBLICATIONS INC
Address	2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
Language	English
Keywords-Plus	IN-VIVO; GOLD NANOPARTICLES; BIODISTRIBUTION; NANOTOXICOLOGY; REACTIVITY; EXPOSURE; MICE
Research-Areas	Pharmacology \& Pharmacy; Toxicology
Web-of-Science-Categories	Pharmacology \& Pharmacy; Toxicology
Author-Email	bkaznelson@etel.ru
ResearcherID-Numbers	Potapov, Alexander/D-8599-2017 Shur, Vladimir/J-9078-2015 Kozitsina, Alisa/S-6317-2017
ORCID-Numbers	Shur, Vladimir/0000-0002-6970-7798
Funding-Acknowledgement	Russian Federal Agency of Science and Innovations
Funding-Text	The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: Financial support provided by Russian Federal Agency of Science and Innovations.
Number-of-Cited-References	25
Usage-Count-Since-2013	13
Journal-ISO	Int. J. Toxicol.
Doc-Delivery-Number	733RJ