SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1,2,4-TRIAZINE DERIVATIVES / Rusinov V. L.,Egorov I. N.,Chupakhin O. N.,Belanov E. F.,Bormotov N. I.,Serova O. A. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2012. - V. 45, l. 11. - P. 655-659.

ISSN/EISSN:

0091-150X / нет данных

Type:

Article

Abstract:

Interaction of 3-aryl-1,2,4-triazin-5(4H)-ones with indole and its methyl derivative in the presence of N-substituted amino acids activated with dicyclohexylcarbodiimide or ethyl chloroformate led to the formation of 1-acyl-6-indolyl-3-phenyl-1,6-dihydro-1,2,4-triazin-5(4H)-ones. The cytotoxic and antiviral actions of the 12 resulting compounds were studied using vaccinia virus.

Author keywords:

1,2,4-Triazines; indoles; naproxen; antiviral activity; amino acids ACYCLIC NUCLEOSIDES; ANALOGS; AGENTS

DOI:

нет данных

Web of Science ID:

ISI:000302105200002

Соавторы в МНС:

Другие поля

Поле	Значение
Month	FEB
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	ACYCLIC NUCLEOSIDES; ANALOGS; AGENTS
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
Author-Email	rusinov@mail.ustu.ru chupakhin@ios.uran.ru belanov@vector.nsc.ru
Funding-Acknowledgement	Analytic Departmental Targeted Program ``Development of Scientific Potential of Higher Schools{''} Program {[}2.1.1/5811, 02.512.11.2237]
Funding-Text	This study was supported by the Analytic Departmental Targeted Program ``Development of Scientific Potential of Higher Schools{''} Program, regulation No. 2.1.1/5811, and State Control No. 02.512.11.2237.
Number-of-Cited-References	23
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	7
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	916LL