New insights in to the treatment of myocardial infarction / Sarapultsev Petr,Chupakhin Oleg,Sarapultsev Alex,Rantsev Maxim,Sidorova Larisa,Medvedeva Svetlana,Danilova Irina // INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. - 2012. - V. 93, l. 1. - P. 18-23.

ISSN/EISSN:

0959-9673 / нет данных

Type:

Article

Abstract:

This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the inflammatory cellular infiltration and myocardial remodelling which occurs after acute myocardial infarction (MI) in rats. The study is based upon recent clinical and experimental work which demonstrated the role of local and systemic inflammatory reactions in postinfarction remodelling. Acute MI in rats was induced by left coronary artery coagulation. Animals were sacrificed on day one, five and seven after MI induction. The myocardiumal samples were taken from all parts of the heart and examined by histology. This included areas of infarction, infraction and areas that were peri-infarctiom and left ventricular areas distant from the damaged tissues. Serum activity of creatine phosphokinase (CPK), aspartate aminotransferase (AST), isoenzymes 1 and 2 and lactate dehydrogenase (LDH1-2) were investigated on the same three days, before and in the process of MI development was investigated (at days 1, 5 and 7). The L-17 compound to not only decreased the area of initial infarction but also changed the pattern of inflammatory reaction in the affected myocardium fundamentally. Laboratory studies of effects of L-17 compound on the development and course of experimental MI showed that administration decreased blood AST and CPK levels significantly and provided useful the data about the correlation between the activity of these enzymes and the dimensions of the significantly necrotic area. In this model of experimental MI the use of the L-17 compound induced led to the replacement of the exudative destructive inflammation that is seen under standard conditions with a more cellular productive pattern of inflammation, with associated reduction in initial necrosis area and the, decrease in myocardial ischaemia and reperfusion injury may account for the accelerated repair process.

Author keywords:

inflammation; L-17 compound; myocardial infarction

DOI:

10.1111/j.1365-2613.2011.00794

Web of Science ID:

ISI:000299334200003

Соавторы в МНС:

Другие поля

Поле	Значение
Month	FEB
Publisher	WILEY-BLACKWELL
Address	COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Language	English
Research-Areas	Pathology
Web-of-Science-Categories	Pathology
Author-Email	Sarapultsev@sky.ru
ResearcherID-Numbers	Sarapultsev, Alexey/K-7220-2012
ORCID-Numbers	Sarapultsev, Alexey/0000-0003-3101-9655
Funding-Acknowledgement	Institute of Immunology and Physiology; Institute of Organic Synthesis, Ural Branch of RAS
Funding-Text	This study was supported by a Special Research Grant of Interdisciplinary project of the Institute of Immunology and Physiology and the Institute of Organic Synthesis, Ural Branch of RAS (2009-2011).
Number-of-Cited-References	18
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	13
Journal-ISO	Int. J. Exp. Pathol.
Doc-Delivery-Number	879MP