Kinetic resolution of (+/-)-2,3-dihydro-3-methyl-4H-1,4-benzoxazines with (S)-naproxen / Charushin VN,Krasnov VP,Levit GL,Korolyova MA,Kodess MI,Chupakhin ON,Kim MH,Lee HS,Park YJ,Kim KC // TETRAHEDRON-ASYMMETRY. - 1999. - V. 10, l. 14. - P. 2691-2702.

ISSN/EISSN:

0957-4166 / нет данных

Type:

Article

Abstract:

A very effective method for the preparation of the (S)-enantiomers of 2,3-dihydro-3-methyl- and 7,8-difluoro-2,3-dihydro-3-methyl-4H- 1,4-benzoxazines (1a and 2a) was developed using (S)-(+)-naproxen acyl chloride as the chiral agent for kinetic resolution of racemates. This method enables one to obtain the (S)-enantiomers of benzoxazines 1a and 2a of high enantiomeric purity (99\% ee) in nearly 50\% yield, taking into account that the (R)-enantiomers are recycled after their racemisation. (C) 1999 Elsevier Science Ltd. All rights reserved.

Author keywords:

ENANTIOMERS; OFLOXACIN

DOI:

10.1016/S0957-4166(99)00276-1

Web of Science ID:

ISI:000082309500010

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL 16
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Keywords-Plus	ENANTIOMERS; OFLOXACIN
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic; Chemistry, Physical
Number-of-Cited-References	17
Usage-Count-Since-2013	2
Journal-ISO	Tetrahedron: Asymmetry
Doc-Delivery-Number	231LB