TRANSFORMATIONS OF 5-DIAZO DERIVATIVES OF 1,3-DIMETHYL-6-HYDRAZINOURACIL - NEW SYNTHETIC APPROACHES TO NOVEL PYRIMIDINE-DERIVATIVES / AZEV YA,GUSELNIKOVA OL,CHUPAKHIN ON // MENDELEEV COMMUNICATIONS. - 1994. - V. , l. 6. - P. 208-209.

ISSN/EISSN:

0959-9436 / нет данных

Type:

Article

Abstract:

1,3-Dimethyl-6-hydrazinouracil 1 gives hydrazones 2 with the corresponding aldehydes. Heating of 6-hydrazinouracil 1 in ethanol in the presence of hydrochloric acid results in the formation of N1,N2-bis(1,3-dimethyl-2,6-dioxopyrimid-4-yl)hydrazine 3, which gives the diazo derivative 4 on treatment with 2,4-diazido-6-cyanomethoxy-s-triazine in DMSO in the presence of triethylamine at room temperature. 5-Diazo derivatives 5 (obtained under similar conditions from reactions between hydrazones 2 and the same 2,4-diazido-6-cyanomethoxy-s-triazine) are subsequently converted into triazolo{[}4.5-d]pyrimidines 6 in nearly quantitative yields after a short period of heating. Hydrazine 1 is transformed into the 2,4,7,9-tetramethyl-1,2,3,4,7,8,9,10-octahydropyrimido{[}4,5-c]-pyridazi no{[}3,4-d]pyrimidin-1,3,8,10-tetrone 7 under diazo-transfer conditions.

Author keywords:

нет данных

DOI:

нет данных

Web of Science ID:

ISI:A1994PV48400004

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	NOV
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF
Language	English
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Number-of-Cited-References	5
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	PV484