SECONDARY STRUCTURE OF THE M2 PROTEIN OF TYPE-A INFLUENZA-VIRUS AND ITS ROLE IN RIMANTADINE AND DEYTIFORINE RESISTANCE / KISELEV OI,MISHIN VP,EROSHKIN VI,KOZELETSKAYA KN,USOVA EV,RUDENKO VI,CHUPAKHIN ON // MOLECULAR BIOLOGY. - 1994. - V. 28, l. 5, 1. - P. 650-653.

ISSN/EISSN:

0026-8933 / нет данных

Type:

Article

Abstract:

Studies on the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow purposeful design of new compounds having a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. Data were obtained concerning the influence of amino acid substitutions in the M2 protein on its secondary structure in the membrane and the role of the protein secondary structure in resistance development.

Author keywords:

RESISTANCE; RIMANTADINE-BINDING SITE; M2 PROTEIN SECONDARY STRUCTURE AMANTADINE

DOI:

нет данных

Web of Science ID:

ISI:A1994QH48100005

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	SEP-OCT
Publisher	PLENUM PUBL CORP
Address	CONSULTANTS BUREAU 233 SPRING ST, NEW YORK, NY 10013
Language	English
Keywords-Plus	AMANTADINE
Research-Areas	Biochemistry \& Molecular Biology
Web-of-Science-Categories	Biochemistry \& Molecular Biology
Number-of-Cited-References	12
Journal-ISO	Mol. Biol.
Doc-Delivery-Number	QH481