IPSO-SUBSTITUTION OF AN ACYL GROUP IN REACTIONS OF 3-ACYL-SUBSTITUTED ETHYL 7,8-DIFLUORO-5-OXO-5,9A-DIHYDROPYRAZOLO{[}1,5-A]QUINOLINE-4-CARBOXYLATES WITH ELECTROPHILIC REAGENTS / AZEV YA,SHORSHNEV SV,ALEXEEV SG,CHARUSHIN VN,CHUPAKHIN ON // MENDELEEV COMMUNICATIONS. - 1993. - V. , l. 3. - P. 99-100.

ISSN/EISSN:

0959-9436 / нет данных

Type:

Article

Abstract:

Reactions of 3-acetyl-(benzoyl-) substituted 7,8-difluoro-5-oxo-5,9a-dihydropyrazolo{[}1,5-a]quinoline-4-carboxylates 1a,b with electrophilic reagents have been studied and reaction of 1 a with methyl iodide in dry DMF in the presence of potassium carbonate results in the corresponding 5-methoxy derivative 2, in which the acetyl group at C-3 is easily substituted by a bromine atom. Treatment of 1a,b with bromine causes ipso-substitution of the acetyl(benzoyl) group accompanied by addition of the second bromine atom at position 4; a similar ipso-substitution of the acetyl group at C-3 has been observed on protonation of 1a with sulfuric acid.

Author keywords:

DEACYLATION; PYRROLES; KETONES

DOI:

нет данных

Web of Science ID:

ISI:A1993LN97600012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF
Language	English
Keywords-Plus	DEACYLATION; PYRROLES; KETONES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Number-of-Cited-References	9
Usage-Count-Since-2013	3
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	LN976