REACTIONS OF N-AMINOQUINOLONES WITH KETONES - A NEW APPROACH TO THE SYNTHESIS OF TRICYCLIC 6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS / CHUPAKHIN ON,AZEV YA,ALEXEEV SG,SHORSHNEV SV,TSOI E,CHARUSHIN VN // MENDELEEV COMMUNICATIONS. - 1992. - V. , l. 4. - P. 151-153.

ISSN/EISSN:

0959-9436 / нет данных

Type:

Article

Abstract:

Reactions of 7-(X)-substituted ethyl 1-amino-4-oxo-1,4-dihydroquinoline-3-carboxylates (1a-c; X = F, Cl and 4-methylpiperazin-1-yl) with mono- and di-ketones have been studied. Treatment of 1a; X = F with cyclohexanone and cyclopentanone in acetic acid resulted in the corresponding azomethynes; alpha-dicarbonyl compounds such as glyoxal, glyoxylic acid or ethyl pyruvate caused desamination of la into ethyl, 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, while reactions of 1a-c with acetoacetone resulted in tricyclic 7-fluoro-4-oxopyrazolo{[}1,5-a]quinoline-4-carboxylic acids.

Author keywords:

нет данных

DOI:

нет данных

Web of Science ID:

ISI:A1992JY83600014

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF
Language	English
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Number-of-Cited-References	14
Usage-Count-Since-2013	1
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	JY836