Some Characteristics of Free Cell Population in the Airways of Rats after Intratracheal Instillation of Copper-Containing Nano-Scale Particles / Privalova Larisa I.,Katsnelson Boris A.,Loginova Nadezhda V.,Gurvich Vladimir B.,Shur Vladimir Y.,Beikin Yakov B.,Sutunkova Marina P.,Minigalieva Ilzira A.,Shishkina Ekaterina V.,Pichugova Svetlana V.,Tulakina Ludmila G.,Beljayeva Svetlana V. // INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - 2014. - V. 15, l. 11. - P. 21538-21553.

ISSN/EISSN:

1422-0067 / нет данных

Type:

Article

Abstract:

We used stable water suspensions of copper oxide particles with mean diameter 20 nm and of particles containing copper oxide and element copper with mean diameter 340 nm to assess the pulmonary phagocytosis response of rats to a single intratracheal instillation of these suspensions using optical, transmission electron, and semi-contact atomic force microscopy and biochemical indices measured in the bronchoalveolar lavage fluid. Although both nano and submicron ultrafine particles were adversely bioactive, the former were found to be more toxic for lungs as compared with the latter while evoking more pronounced defense recruitment of alveolar macrophages and especially of neutrophil leukocytes and more active phagocytosis. Based on our results and literature data, we consider both copper solubilization and direct contact with cellular organelles (mainly, mitochondria) of persistent particles internalized by phagocytes as probable mechanisms of their cytotoxicity.

Author keywords:

ultrafine copper-containing particles; bronchoalveolar lavage; cytotoxicity OXIDE NANOPARTICLES; CUO NANOPARTICLES; IN-VIVO; SILVER NANOPARTICLES; CYTOTOXIC ACTION; GENOTOXICITY; MECHANISMS; TOXICITY; BIOPROTECTORS; ATTENUATION

DOI:

10.3390/ijms151121538

Web of Science ID:

ISI:000345529200128

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	MDPI AG
Address	POSTFACH, CH-4005 BASEL, SWITZERLAND
Language	English
Keywords-Plus	OXIDE NANOPARTICLES; CUO NANOPARTICLES; IN-VIVO; SILVER NANOPARTICLES; CYTOTOXIC ACTION; GENOTOXICITY; MECHANISMS; TOXICITY; BIOPROTECTORS; ATTENUATION
Research-Areas	Biochemistry \& Molecular Biology; Chemistry
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Chemistry, Multidisciplinary
Author-Email	privalovali@yahoo.com bkaznelson@etel.ru loginova.Nadzhda@mail.ru gurvich@ymrc.ru vladimir.shur@usu.ru beikin@mail.ru sutunkova@ymrc.ru ilzira-minigalieva@yandex.ru ekaterina.shishkina@labfer.usu.ru ekb-lem@mail.ru sdiklein@gmail.com kdc\_boss@mail.ru
ResearcherID-Numbers	Shishkina, Ekaterina/I-1829-2017 Shur, Vladimir/J-9078-2015
ORCID-Numbers	Shishkina, Ekaterina/0000-0002-2574-7472
Number-of-Cited-References	28
Usage-Count-Since-2013	15
Journal-ISO	Int. J. Mol. Sci.
Doc-Delivery-Number	AU3QR