Determination of the iron state in ferrous iron containing vitamins and dietary supplements: Application of Mossbauer spectroscopy / Oshtrakh MI,Milder OB,Semionkin VA // JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - 2006. - V. 40, l. 5. - P. 1281-1287.

ISSN/EISSN:

0731-7085 / 1873-264X

Type:

Article

Abstract:

Determination of the iron state in commercially manufactured iron containing vitamins and dietary supplements is important for evaluation of pharmaceuticals quality. Mossbauer (nuclear gamma-resonance) spectroscopy was used for analyzing the iron state in commercial pharmaceutical products containing ferrous fumarate (FeC4H2O4), ferrous sulfate (FeSO4), ferrous bisglycinate chelate (Ferrochel (R)) and ferrous iron (hydrolyzed protein chelate). Mossbauer parameters and the iron states were determined for iron compounds in the studied pharmaceuticals. Various ferric and ferrous impurities were found in all of the commercial products. The quantities of ferric impurities exceeded the FDA limitation of 2\% in products containing ferrous fumarate. The quantities of ferric impurities exceeded 58\% and 30\% in products containing ferrous bisglycinate chelate and ferrous iron (hydrolyzed protein chelate), respectively. The presence of ferrous and ferric impurities was not related to the ageing of the vitamins and dietary Supplements. Two pharmaceutical products contained major iron compounds, the Mossbauer parameters of which did not correspond to the ferrous fumarate or ferrous bisglycinate chelate claimed by the manufacturer. (c) 2005 Elsevier B.V. All rights reserved.

Author keywords:

vitamins and dietary supplements; ferrous fumarate; ferrous sulfate; ferrous bisglycinate chelate (Ferrochel (R)); ferrous iron (hydrolyzed protein chelate); iron state; Mossbauer spectroscopy BIS-GLYCINATE CHELATE; X-RAY-DIFFRACTION; DEXTRAN COMPLEXES; DEFICIENCY ANEMIA; SULFATE; FUMARATE; SAFETY; FERROCHEL; FERRITIN; CHILDREN

DOI:

10.1016/j.jpba.2005.09.020

Web of Science ID:

ISI:000236234900035

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR 18
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1873-264X
Keywords-Plus	BIS-GLYCINATE CHELATE; X-RAY-DIFFRACTION; DEXTRAN COMPLEXES; DEFICIENCY ANEMIA; SULFATE; FUMARATE; SAFETY; FERROCHEL; FERRITIN; CHILDREN
Research-Areas	Chemistry; Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Analytical; Pharmacology \& Pharmacy
Author-Email	oshtrakh@mail.utnet.ru
ResearcherID-Numbers	Oshtrakh, Mikhail/L-8342-2016
ORCID-Numbers	Oshtrakh, Mikhail/0000-0002-2937-5194
Number-of-Cited-References	35
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	18
Journal-ISO	J. Pharm. Biomed. Anal.
Doc-Delivery-Number	024ZK