Hyperfine interactions in the iron cores from various pharmaceutically important iron-dextran complexes and human ferritin: a comparative study by Mossbauer spectroscopy / Oshtrakh MI,Semionkin VA,Prokopenko PG,Milder OB,Livshits AB,Kozlov AA // INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. - 2001. - V. 29, l. 4-5. - P. 303-314.

ISSN/EISSN:

0141-8130 / 1879-0003

Type:

Article

Abstract:

Mossbauer spectroscopy has been used to study the hyperfine interactions in the iron cores of pharmaceutically important industrial and elaborated iron-dextran complexes (ferritin models) and human ferritin. Mossbauer spectra of frozen solutions and lyophilized samples of iron-dextran complexes at 87 K demonstrated magnetic, superparamagnetic and paramagnetic states of iron in various complexes. Mossbauer spectra of human ferritin in frozen solution and lyophilized form showed paramagnetic state of iron at 87 K. Small variations of Mossbauer hyperfine parameters were observed for different samples at 87 and 295 K, respectively, supposing the homogenous iron cores. The values of quadrupole splitting for iron-dextran complexes and ferritin in frozen solutions at 87 K varied from 0.639 to 0.744 mm/s while those of lyophilized samples at 87 K varied from 0.714 to 0.788 mm/s. The values of quadrupole splitting for iron-dextran complexes and ferritin in lyophilized form at 295 K varied from 0.687 to 0.741 mm/s. The values of hyperfine magnetic fields on the Fe-57 nuclei in several iron-dextran complexes at 87 K varied from similar to 231 to similar to 485 kOe. These small variations of the hyperfine parameters were related to several types of the hydrous iron oxide microstructural modifications in the core and variations of the iron core size. The influence of lyophilization on the iron core structure was also assumed. In addition, Mossbauer spectra were evaluated in supposition of heterogeneous iron core in all samples. (C) 2001 Elsevier Science B.V. All rights reserved.

Author keywords:

iron-dextran complexes; ferritin; iron core; hyperfine interactions; Mossbauer spectroscopy X-RAY ABSORPTION; HORSE SPLEEN FERRITIN; POSITRON-ANNIHILATION; OXIDE DEPOSITS; HEME IRON; ELECTRON-DIFFRACTION; MAGNETIC-PROPERTIES; SPECTRA; IMFERON; FORM

DOI:

10.1016/S0141-8130(01)00181-7

Web of Science ID:

ISI:000172670700012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	DEC 10
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1879-0003
Keywords-Plus	X-RAY ABSORPTION; HORSE SPLEEN FERRITIN; POSITRON-ANNIHILATION; OXIDE DEPOSITS; HEME IRON; ELECTRON-DIFFRACTION; MAGNETIC-PROPERTIES; SPECTRA; IMFERON; FORM
Research-Areas	Biochemistry \& Molecular Biology; Chemistry; Polymer Science
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Chemistry, Applied; Polymer Science
Author-Email	oshtrakh@mail.utnet.ru
ResearcherID-Numbers	Oshtrakh, Mikhail/L-8342-2016
ORCID-Numbers	Oshtrakh, Mikhail/0000-0002-2937-5194
Number-of-Cited-References	52
Usage-Count-Since-2013	1
Journal-ISO	Int. J. Biol. Macromol.
Doc-Delivery-Number	501EX