Effect of cytoskeletal elastic properties on the mechanoelectrical transduction in excitable cells / Shklyar Tatyana F.,Dinislamova Olga A.,Safronov Alexander P.,Blyakhman Felix A. // JOURNAL OF BIOMECHANICS. - 2012. - V. 45, l. 8. - P. 1444-1449.

ISSN/EISSN:

0021-9290 / нет данных

Type:

Article

Abstract:

This paper addresses the possible mechanism of stretch on cell electrochemical potential change, based on the physicochemical properties of cytoskeletal network. Synthetic polyelectrolyte gel was used as an experimental model of the cytoskeleton. Gel samples with different density of network cross linking were studied. Triangular axial deformations of samples were applied. Simultaneously, the electrochemical (Donnan) potential of the gel was measured between a micropipette electrode pinned into the swollen gel, and a reference electrode in the outer solution. We found that axial deformation shifts the gel potential toward depolarization. The extent of gel depolarization showed a close negative correlation with the Young modulus of the gel. We suggest that the underlying mechanism is likely to be a universal process of counterion adsorption on charged polymer filaments due to the decrease of distance between polymer filaments owing to gel elongation. (C) 2012 Elsevier Ltd. All rights reserved.

Author keywords:

Cytoskeleton; Polyelectrolyte gel; Electrochemical potential; Mechanoelectrical transduction SINGLE-VENTRICULAR MYOCYTES; MEMBRANE CURRENTS; MOLECULAR-BASIS; ION CHANNELS; STRETCH; FEEDBACK; ACTIVATION; ACTIN; MECHANOTRANSDUCTION; FIBROBLASTS

DOI:

10.1016/j.jbiomech.2012.02.017

Web of Science ID:

ISI:000304216100016

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY 11
Publisher	ELSEVIER SCI LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Language	English
Keywords-Plus	SINGLE-VENTRICULAR MYOCYTES; MEMBRANE CURRENTS; MOLECULAR-BASIS; ION CHANNELS; STRETCH; FEEDBACK; ACTIVATION; ACTIN; MECHANOTRANSDUCTION; FIBROBLASTS
Research-Areas	Biophysics; Engineering
Web-of-Science-Categories	Biophysics; Engineering, Biomedical
Author-Email	felix.bljakhman@usu.ru
ResearcherID-Numbers	Blyakhman, Felix/B-7807-2011
ORCID-Numbers	Blyakhman, Felix/0000-0003-4434-2873
Number-of-Cited-References	43
Usage-Count-Last-180-days	6
Usage-Count-Since-2013	23
Journal-ISO	J. Biomech.
Doc-Delivery-Number	944PK