Synthesis of 7-cycloalkylimino substituted 3-amino-6-fluoro-2-methyl-3H-quinazolin-4-ones / Nosova Emiliya V.,Lipunova Galina N.,Slepukhin Pavel A.,Charushin Valery N. // JOURNAL OF FLUORINE CHEMISTRY. - 2013. - V. 145, l. . - P. 63-65.

ISSN/EISSN:

0022-1139 / нет данных

Type:

Article

Abstract:

A versatile pathway for the synthesis of 7-cycloalkylimino substituted 3-amino-6-fluoro-2-methyl-3H-quinazolin-4-ones from 4,5-difluoroanthranylic acid has been advanced. Nucleophilic amination-defluorination reaction of the 6,7-difluoro derivative of 3-amino-2-methyl-3H-quinazolin-4-one has been established to occur at position 7, as shown by X-ray crystallographic analysis. (c) 2012 Elsevier B.V. All rights reserved.

Author keywords:

Fluorine-containing quinazolinones; 3-Aminoquinazolin-4-ones; Nucleophilic displacement reactions; X-ray crystallography INHIBITORS

DOI:

10.1016/j.jfluchem.2012.10.003

Web of Science ID:

ISI:000315252900008

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN
Publisher	ELSEVIER SCIENCE SA
Address	PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Language	English
Keywords-Plus	INHIBITORS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic
Author-Email	emily74@rambler.ru lipunova@ios.uran.ru
Funding-Acknowledgement	Ministry of Education and Science {[}3.1941.2011]; Russian Foundation for Basic Research {[}11-03-00718]
Funding-Text	This work was supported by the Ministry of Education and Science (grant 3.1941.2011) and by the Russian Foundation for Basic Research (grant 11-03-00718).
Number-of-Cited-References	12
Usage-Count-Since-2013	5
Journal-ISO	J. Fluor. Chem.
Doc-Delivery-Number	094HF