Synthesis and antiviral activity of fluorine-containing 4-arylaminoquinazolines / Lipunova G. N.,Nosova E. V.,Laeva A. A.,Charushin V. N. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2012. - V. 45, l. 12. - P. 709-711.

ISSN/EISSN:

0091-150X / нет данных

Type:

Article

Abstract:

2-Methylthio-4-phenylamino-6,7,8-trifluoro-3H-quinazolin-4-one was synthesized by means of intramolecular cyclizations of S-methyl-N-(tetrafluorobenzoyl)isothiourea followed by a reaction with POCl3 and nucleophilic substitution at the 4-position. The reactions of the synthesized compound with amines proceed, depending on their nature, via substitution of either the F(7) atom or the SMe fragment in the 2-position. The antiviral activity of the obtained 6,7,8-trifluoro-2-ethylthioquinazolin-4-ones was investigated using monkeypox virus, smallpox vaccine, and ectromelia virus. It is shown that fluorinated quinazoline derivatives have good prospects in the search for new active substances.

Author keywords:

2-methylthio-4-phenylamino-6,7,8-trifluoro-3H-quinazolin-4-one; 6,7,8-trifluoro-2-ethylthioquinazolin-4-ones; synthesis; antiviral activity INFECTIONS

DOI:

10.1007/s11094-012-0707-2

Web of Science ID:

ISI:000303534900002

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	INFECTIONS
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
Author-Email	lipunova@ios.uran.ru emily74@rambler.ru
Funding-Acknowledgement	Scientific Schools Grant {[}NSh-65261.2010.3]; {[}GK-02.740.11.0260]
Funding-Text	The work was supported financially by State Contract GK-02.740.11.0260 and a Scientific Schools Grant NSh-65261.2010.3.
Number-of-Cited-References	15
Usage-Count-Since-2013	1
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	935QL