Synthesis of 5-and 7-fluoroquinazolin-4(1H)-ones / Layeva A. A.,Nosova E. V.,Lipunova G. N.,Trashakhova T. V.,Charushin V. N. // RUSSIAN CHEMICAL BULLETIN. - 2007. - V. 56, l. 9. - P. 1821-1827.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

5-Fluoroquinazoline-2,4-diones and their 2-thio analogs were obtained from 6-fluoroanthranilic acid. Two convenient routes to 5-fluoroquinazolin-4-ones involved cyclocondensation of 6-fluoroanthranilamide with acid chlorides (anhydrides) or with aromatic (heterocyclic) aldehydes. A method for the synthesis of 7-fluoroquinazolin-4-one from 2,4-difluorobenzoic acid was proposed.

Author keywords:

fluoro-containing quinazolin-4-ones; quinazoline-2; 4-dione; 2-amino-6-fluorobenzonitrile; 6-fluoroanthranilamide; 6-fluoroanthranilic acid; 2; 4-difluorobenzonitrile; cyclocondensation; Schiff bases TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; ANTICANCER AGENTS; DERIVATIVES; POTENT; 4(3H)-QUINAZOLINONES; ACID

DOI:

10.1007/s11172-007-0283-x

Web of Science ID:

ISI:000254206200022

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP
Publisher	SPRINGER
Address	233 SPRING STREET, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; ANTICANCER AGENTS; DERIVATIVES; POTENT; 4(3H)-QUINAZOLINONES; ACID
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	charushin@ios.uran.ru
Number-of-Cited-References	31
Usage-Count-Since-2013	1
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	277IP