A new approach to fluorinated 4(3H)-quinazolinones / Layeva Anastacia A.,Nosova Emilia V.,Lipunova Galina N.,Trashakhova Tatyana V.,Charushin Valerii N. // JOURNAL OF FLUORINE CHEMISTRY. - 2007. - V. 128, l. 7, SI. - P. 748-754.

ISSN/EISSN:

0022-1139 / нет данных

Type:

Article; Proceedings Paper

Abstract:

A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at I-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out. (c) 2007 Published by Elsevier B.V.

Author keywords:

fluorine-containing quinazolinones; intramolecular cyclization; nucleophilic substitution; S-ethyl N-benzoylisothioureas TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; DERIVATIVES; POTENT; 2-AMINOBENZONITRILE; QUINAZOLINONES; ANALOGS

DOI:

10.1016/j.fluchem.2007.03.005

Web of Science ID:

ISI:000248429900012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL
Note	7th All-Russian Conference on Fluorine Chemistry, INEOS, Moscow, RUSSIA, JUN 05-09, 2006
Publisher	ELSEVIER SCIENCE SA
Address	PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Language	English
Keywords-Plus	TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; DERIVATIVES; POTENT; 2-AMINOBENZONITRILE; QUINAZOLINONES; ANALOGS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic
Author-Email	charushin@ios.uran.ru
Number-of-Cited-References	29
Usage-Count-Since-2013	2
Journal-ISO	J. Fluor. Chem.
Doc-Delivery-Number	195RS