Fused fluoroquinolones: synthesis and H-1 and F-19 NMR studies / Charushin VN,Nosova EV,Lipunova GN,Kodess MI // JOURNAL OF FLUORINE CHEMISTRY. - 2001. - V. 110, l. 1. - P. 25-30.

ISSN/EISSN:

0022-1139 / нет данных

Type:

Article

Abstract:

New derivatives of fused fluoroquinolones bearing five aromatic rings have been obtained. The F-19 NMR spectra of these pentacyclic fluoroquinolones demonstrate unusual through space H-1-F-19 and F-19-F-19 spin-spin interactions with coupling constants (6)J(F, H) = 2.0-3.0 Hz, (7)J(F, F) = 3.5-4.0 Hz and (9)J(F, H) = 3.0-3.5 Hz. Relative reactivities of fluorine atoms in pentacyclic fluoroquinolones in the amino-defluorination reactions are also different relative to bi- and tricyclic fluoroquinolones. (C) 2001 Elsevier Science B.V. All rights reserved.

Author keywords:

fused fluoroquinolones; H-1 and F-19 NMR spectra; long range coupling constants; amino-defluorination

DOI:

10.1016/S0022-1139(01)00402-X

Web of Science ID:

ISI:000170257800005

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL 25
Publisher	ELSEVIER SCIENCE SA
Address	PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Language	English
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Chemistry, Organic
Number-of-Cited-References	19
Journal-ISO	J. Fluor. Chem.
Doc-Delivery-Number	459NU