Synthesis, Crystal Structure and Biological Activity of N-(tert-butyl)-N `-(2-(4-chlorophenyl)acetyl)-5-methyl-1,2,3-thiadiazole-4-carbohydrazide / Wang Dun ,Mao Wu-Tao ,Fan Zhi-Jin ,Li Juan-Juan ,Huang Yun ,Song Hai-Bin ,Fan Qian ,Kalinina Tatiana A.,Tatiana Glukhareva,Yur'evich Morzherin Yury,Pavlovna Belskaya N.,Alekseevich Bakulev V. // CHINESE JOURNAL OF STRUCTURAL CHEMISTRY. - 2013. - V. 32, l. 5. - P. 673-678.

ISSN/EISSN:

0254-5861 / нет данных

Type:

Article

Abstract:

The title compound N-(tert-butyl)-N'-(2-(4-chlorophenyl)acetyl)-5-methyl-1,2,3-thiadiazole- 4-carbohydrazide (C16H19ClN4NaO2S, M-r = 366.86) has been synthesized, and its structure was characterized by IR, H-1 NMR, H RMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to triclinic, space group P (1) over bar with a = 8.464(2), b = 10.192(2), c = 11.757(2) angstrom, alpha = 68.48(3), beta = 76.31(3), gamma = 80.86(3)degrees, Z = 2, V = 2024.6(10) angstrom(3), D-c = 1.333 g/cm(3), mu = 0.339 mm(-1), F(000) = 384, R = 0.0450 and wR (I> 2 sigma(I)) = 0.1234. X-ray analysis indicates one N-H center dot center dot center dot N intermolecular hydrogen bond and no pi-pi stacking interactions are observed in this crystal structure. The preliminary biological test shows that the title compound has fungicidal activity and antivirus activities against tobacco mosaic virus.

Author keywords:

X-ray diffraction; crystal structure; synthesis; 1,2,3-thiadiazole; biological activity 1,2,3-THIADIAZOLE DERIVATIVES; INSECTICIDAL EVALUATION

DOI:

нет данных

Web of Science ID:

ISI:000319637100008

Соавторы в МНС:

Другие поля

Поле	Значение
Publisher	CHINESE JOURNAL STRUCTURAL CHEMISTRY
Address	FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA
Language	English
Keywords-Plus	1,2,3-THIADIAZOLE DERIVATIVES; INSECTICIDAL EVALUATION
Research-Areas	Chemistry; Crystallography
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Crystallography
Author-Email	fanzj@nankai.edu.cn 5787huangyun@sina.com
ResearcherID-Numbers	Morzherin, Yury/M-7420-2013
ORCID-Numbers	Morzherin, Yury/0000-0002-1333-6676
Funding-Acknowledgement	NNSFC {[}20872071]; NSF of Tianjin {[}10JCZDJC17500]; National Key Project for Basic Research {[}2010CB126105]; National Key Technology Research and Development Program {[}2011BAEO6B02, 2011BAEO6B05]; Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology {[}201002250]; Tianjin Key Technology Research and Development Program {[}11ZCGYNC00100]
Funding-Text	This study was funded in part by the NNSFC (20872071), the NSF of Tianjin (10JCZDJC17500), the National Key Project for Basic Research (2010CB126105) and National Key Technology Research and Development Program (2011BAEO6B02 and 2011BAEO6B05) and the Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology (201002250), Tianjin Key Technology Research and Development Program (11ZCGYNC00100)
Number-of-Cited-References	19
Usage-Count-Since-2013	14
Journal-ISO	Chin. J. Struct. Chem.
Doc-Delivery-Number	153XW