Synthesis and bioactivity of N-tert-butyl-N `-acyl-5-methy 1-1,2,3-thiadiazole-4-carbohydrazides / Mao Wu Tao,Zhao Hui,Fan Zhi Jin,Ji Xiao Tian,Hua Xue Wen,Kalinina Tatiana,Yury Yu Morzherin,Vasiliy A. Bakulev // CHINESE CHEMICAL LETTERS. - 2012. - V. 23, l. 11. - P. 1233-1236.

ISSN/EISSN:

1001-8417 / нет данных

Type:

Article

Abstract:

A series of novel N-tert-butyl-N'-acyl-5-methyl-1,2,3-thiadiazole-4-carbohyclrazides were designed and synthesized. Their structures were characterized by melting points, H-1 NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in viva at 50 mu g/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. (C) 2012 Zhi Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Author keywords:

Antivirus activity; Systemic acquired resistance; Synthesis; 1,2,3-Thiadiazole; Diacylhydrazine SYSTEMIC ACQUIRED-RESISTANCE; 1,2,3-THIADIAZOLE DERIVATIVES; BIOLOGICAL-ACTIVITY

DOI:

10.1016/j.cclet.2012.09.024

Web of Science ID:

ISI:000311979300006

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	ELSEVIER SCIENCE INC
Address	360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Language	English
Keywords-Plus	SYSTEMIC ACQUIRED-RESISTANCE; 1,2,3-THIADIAZOLE DERIVATIVES; BIOLOGICAL-ACTIVITY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	fanzj@nankai.edu.cn
ResearcherID-Numbers	Morzherin, Yury/M-7420-2013
ORCID-Numbers	Morzherin, Yury/0000-0002-1333-6676
Funding-Acknowledgement	NNSFC {[}20872071]; NSF of Tianjin {[}10JCZDJC17500]; National Key Project for Basic Research {[}2010CB126105]; National Key Technology Research and Development Program {[}2011BAE06B02, 2011BAE06B05]; Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology {[}201002250]; Tianjin Key Technology Research and Development Program {[}11ZCGYNC00100]
Funding-Text	This study was funded in part by the NNSFC (No. 20872071), the NSF of Tianjin (No. 10JCZDJC17500), the National Key Project for Basic Research (No. 2010CB126105) and National Key Technology Research and Development Program (Nos. 2011BAE06B02 and 2011BAE06B05) and the Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology (No. 201002250), Tianjin Key Technology Research and Development Program (No. 11ZCGYNC00100).
Number-of-Cited-References	19
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	30
Journal-ISO	Chin. Chem. Lett.
Doc-Delivery-Number	049JN