Electrical Wave Propagation in an Anisotropic Model of the Left Ventricle Based on Analytical Description of Cardiac Architecture / Pravdin Sergey F.,Dierckx Hans,Katsnelson Leonid B.,Solovyova Olga,Markhasin Vladimir S.,Panfilov Alexander V. // PLOS ONE. - 2014. - V. 9, l. 5.

ISSN/EISSN:

1932-6203 / нет данных

Type:

Article

Abstract:

We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher-Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.

Author keywords:

EXCITABLE MEDIUM; FIBER ROTATION; TISSUE MODEL; HEART; MYOCARDIUM; REENTRY; FIBRILLATION; ACTIVATION; MECHANISMS; VORTICES

DOI:

10.1371/journal.pone.0093617

Web of Science ID:

ISI:000336838000004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY 9
Publisher	PUBLIC LIBRARY SCIENCE
Address	1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
Language	English
Article-Number	e93617
Keywords-Plus	EXCITABLE MEDIUM; FIBER ROTATION; TISSUE MODEL; HEART; MYOCARDIUM; REENTRY; FIBRILLATION; ACTIVATION; MECHANISMS; VORTICES
Research-Areas	Science \& Technology - Other Topics
Web-of-Science-Categories	Multidisciplinary Sciences
Author-Email	sergey.pravdin@ugent.be alexander.panfilov@ugent.be
ResearcherID-Numbers	Panfilov, Alexander/G-8459-2016 Pravdin, Sergei/O-8888-2016 Solovyova, Olga/T-8232-2017
ORCID-Numbers	Panfilov, Alexander/0000-0003-2643-642X Pravdin, Sergei/0000-0003-4053-8895
Funding-Acknowledgement	Presidium of Urals Branch of the Russian Academy of Sciences {[}12-M-14-2009]; Flemish Community of Belgium {[}1F2B8M/JDW/2010-2011/10-BTL-RUS-01]; Ghent University {[}01SF1511]; UrFU {[}02.A03.21.0006]; program ``State Support of the Leading Scientific Schools{''} {[}NS-4538.2014.1]; Russian Foundation for Basic Research {[}13-01-96048]; Government of the Sverdlovsk Region
Funding-Text	This work was supported by the Presidium of Urals Branch of the Russian Academy of Sciences (project 12-M-14-2009), the Flemish Community of Belgium (HD's fellowship and grant 1F2B8M/JDW/2010-2011/10-BTL-RUS-01), Ghent University (grant 01SF1511), the Agreement 211 between the Government of RF and UrFU \#02.A03.21.0006, the program ``State Support of the Leading Scientific Schools{''} (NS-4538.2014.1), the Russian Foundation for Basic Research (grant 13-01-96048) and the Government of the Sverdlovsk Region. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Number-of-Cited-References	66
Usage-Count-Since-2013	31
Journal-ISO	PLoS One
Doc-Delivery-Number	AI4LX