Slow force response and auto-regulation of contractility in heterogeneous myocardium / Markhasin Vladimir S.,Balakin Alexander A.,Katsnelson Leonid B.,Konovalov Pavel,Lookin Oleg N.,Protsenko Yuri,Solovyova Olga // PROGRESS IN BIOPHYSICS \& MOLECULAR BIOLOGY. - 2012. - V. 110, l. 2-3, SI. - P. 305-318.

ISSN/EISSN:
0079-6107 / нет данных
Type:
Review
Abstract:
Classically, the slow force response (SFR) of myocardium refers to slowly developing changes in cardiac muscle contractility induced by external mechanical stimuli, e.g. sustained stretch. We present evidence for an intra-myocardial SFR (SFRIM), caused by the internal mechanical interactions of muscle segments in heterogeneous myocardium. Here we study isometric contractions of a pair of end-to-end connected functionally heterogeneous cardiac muscles (an in-series muscle duplex). Duplex elements can be either biological muscles (BM), virtual muscles (VM), or a hybrid combination of BM and VM. The VM implements an Ekaterinburg-Oxford mathematical model accounting for the ionic and myofilament mechanisms of excitation-contraction coupling in cardiomyocytes. SFRIM is expressed in gradual changes in the overall duplex force and in the individual contractility of each muscle, induced by cyclic auxotonic deformations of coupled muscles. The muscle that undergoes predominant cyclic shortening shows force enhancement upon return to its isometric state in isolation, whereas average cyclic lengthening may decrease the individual muscle contractility. The mechanical responses are accompanied with slow and opposite changes in the shape and duration of both the action potential and Ca2+ transient in the cardiomyocytes of interacting muscles. Using the mathematical model we found that the contractility changes in interacting muscles follow the alterations in the sarcoplasmic reticulum loading in cardiomyocytes which result from the length-dependent Ca2+ activation of myofilaments and intracellular mechano-electrical feedback. The SFRIM phenomena unravel an important mechanism of cardiac functional auto-regulation applicable to the heart in norm and pathology, especially to hearts with severe electrical and/or mechanical dyssynchrony. (C) 2012 Elsevier Ltd. All rights reserved.
Author keywords:
Myocardial mechanics; Cardiomyocyte; Stretch; Shortening; Cooperativity; Excitation-contraction coupling; Cardiac mechano-electric coupling; Electromechanical mathematical model STRETCH-ACTIVATED CHANNELS; VENTRICULAR MYOCYTES; CARDIAC-MUSCLE; ION CHANNELS; MECHANOELECTRIC FEEDBACK; CELLULAR MECHANISMS; MATHEMATICAL-MODEL; THEORETICAL-MODELS; AXIAL STRETCH; HEART
DOI:
10.1016/j.pbiomolbio.2012.08.0
Web of Science ID:
ISI:000311476100015
Соавторы в МНС:
Другие поля
Поле Значение
Month OCT-NOV
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Address THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language English
Keywords-Plus STRETCH-ACTIVATED CHANNELS; VENTRICULAR MYOCYTES; CARDIAC-MUSCLE; ION CHANNELS; MECHANOELECTRIC FEEDBACK; CELLULAR MECHANISMS; MATHEMATICAL-MODEL; THEORETICAL-MODELS; AXIAL STRETCH; HEART
Research-Areas Biochemistry \& Molecular Biology; Biophysics
Web-of-Science-Categories Biochemistry \& Molecular Biology; Biophysics
Author-Email O.Solovyova@iip.uran.ru
ResearcherID-Numbers Konovalov, Pavel/D-9838-2015 Lookin, Oleg/H-7454-2014 Solovyova, Olga/T-8232-2017 Protsenko, Yuri/G-7185-2016
ORCID-Numbers Lookin, Oleg/0000-0001-9544-1885 Protsenko, Yuri/0000-0002-4693-244X Balakin, Alexander/0000-0002-7712-6686
Funding-Acknowledgement Ural Branch of Russian Academy of Sciences {[}12-M-14-2009, 12-II-4-1067]; Russian Basic Research Foundation {[}10-04-00601-a, 11-04-00785-a]; Wellcome Trust UK-Russia collaboration grant
Funding-Text We are indebted to Professor Peter Kohl for the helpful discussions throughout this project, and to Dr. Nico Kuijpers for invaluable comments on the manuscript. This work is supported by the Ural Branch of Russian Academy of Sciences (12-M-14-2009, 12-II-4-1067) and Russian Basic Research Foundation (10-04-00601-a, 11-04-00785-a). Pilot studies further benefited from a Wellcome Trust UK-Russia collaboration grant.
Number-of-Cited-References 59
Usage-Count-Since-2013 19
Journal-ISO Prog. Biophys. Mol. Biol.
Doc-Delivery-Number 042MU