Contribution of mechanical factors to arrhythmogenesis in calcium overloaded cardiomyocytes: Model predictions and experiments / Katsnelson Leonid B.,Solovyova Olga,Balakin Alexander,Lookin Oleg,Konovalov Pavel,Protsenko Yuri,Sulman Tatiana,Markhasin Vladimir S. // PROGRESS IN BIOPHYSICS \& MOLECULAR BIOLOGY. - 2011. - V. 107, l. 1. - P. 81-89.

ISSN/EISSN:

0079-6107 / нет данных

Type:

Review

Abstract:

It is well-known that Ca(2+) overload in cardiomyocytes may underlie arrhythmias. However, the possible contribution of mechanical factors to rhythm disturbances in Ca(2+) overloaded myocytes has not been sufficiently investigated. We used a mathematical model of the electrical and mechanical activity of cardiomyocytes to reveal an essential role of the mechanisms of cardiac mechano-electric feedback in arrhythmogenesis in Ca(2+) overloaded myocardium. In the model, the following mechanical factors increased Ca(2+) overload in contracting cardiomyocytes and promoted rhythm disturbances: i) a decrease in the mechanical load for afterloaded contractions; and ii) a decrease in the initial length of sarcomeres for isometric twitches. In exact accordance with the model predictions, in experiments on papillary muscles from the right ventricle of guinea pigs with Ca(2+) overloaded cardiomyocytes (using 0.5-1 mu M of ouabain), we found that emergence of rhythm disturbances and extrasystoles depends on the mechanical conditions of muscle contraction. (C) 2011 Elsevier Ltd. All rights reserved.

Author keywords:

Myocardium mechanics; Heart rhythm; Extrasystole; Mechano-electric coupling MAMMALIAN VENTRICULAR-MUSCLE; FAILING HUMAN MYOCARDIUM; STRETCH-INDUCED CHANGES; CAT PAPILLARY-MUSCLE; RAT CARDIAC-MUSCLE; INTRACELLULAR CALCIUM; MATHEMATICAL-MODEL; FORCE RESPONSE; ION CHANNELS; CA2+ WAVES

DOI:

10.1016/j.pbiomolbio.2011.06.0

Web of Science ID:

ISI:000296544000009

Соавторы в МНС:

Другие поля

Поле	Значение
Month	OCT
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Keywords-Plus	MAMMALIAN VENTRICULAR-MUSCLE; FAILING HUMAN MYOCARDIUM; STRETCH-INDUCED CHANGES; CAT PAPILLARY-MUSCLE; RAT CARDIAC-MUSCLE; INTRACELLULAR CALCIUM; MATHEMATICAL-MODEL; FORCE RESPONSE; ION CHANNELS; CA2+ WAVES
Research-Areas	Biochemistry \& Molecular Biology; Biophysics
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Biophysics
Author-Email	l.katsnelson@iip.uran.su
ResearcherID-Numbers	Lookin, Oleg/H-7454-2014 Konovalov, Pavel/D-9838-2015 Solovyova, Olga/T-8232-2017 Protsenko, Yuri/G-7185-2016
ORCID-Numbers	Lookin, Oleg/0000-0001-9544-1885 Protsenko, Yuri/0000-0002-4693-244X Balakin, Alexander/0000-0002-7712-6686
Funding-Acknowledgement	Ural Branch of RAS {[}RBRF 10-04-00601-a, 11-04-00785-a]
Funding-Text	This work is supported by the Ural Branch of RAS, RBRF 10-04-00601-a, 11-04-00785-a.
Number-of-Cited-References	37
Usage-Count-Since-2013	19
Journal-ISO	Prog. Biophys. Mol. Biol.
Doc-Delivery-Number	841VT