Activation sequence as a key factor in spatio-temporal optimization of myocardial function / Solovyova O,Katsnelson LB,Konovalov P,Lookin O,Moskvin AS,Protsenko YL,Vikulova N,Kohl P,Markhasin VS // PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. - 2006. - V. 364, l. 1843. - P. 1367-1383.

ISSN/EISSN:

1364-503X / нет данных

Type:

Article

Abstract:

Using one-dimensional models of myocardial tissue, implemented as chains of virtual ventricular muscle segments that are kinematically connected in series, we studied the role of the excitation sequence in spatio-temporal organization of cardiac function. Each model element was represented by a well-verified mathematical model of cardiac electromechanical activity. We found that homogeneous chains, consisting of identical elements, respond to non-simultaneous stimulation by generation of complex spatio-temporal heterogeneities in element deformation. These are accompanied by the establishment of marked gradients in local electro-mechanical properties of the elements (heterogeneity in action potential duration, Ca2+ transient characteristics and sarcoplasmic reticulum Ca2+ loading). In heterogeneous chains, composed of elements simulating fast and slow contracting cardiomyocytes from different transmural layers, we found that only activation sequences where stimulation of the slower elements preceded that of faster ones gave rise to optimization of the system's electro-mechanical function. which was confirmed experimentally. Based on the results obtained, we hypothesize that the sequence of activation of cardiomyocytes in different ventricular layers is one of the key factors of spatio-temporal organization of myocardium. Moreover, activation sequence and regional differences in intrinsic electro-mechanical properties of cardiac muscle must be matched in order to optimize myocardial function.

Author keywords:

myocardium heterogeneity; time delays; spatio-temporal organization; mechano-electric feedback CARDIAC-MUSCLE; HETEROGENEOUS MYOCARDIUM; LEFT-VENTRICLE; MODELS; HEART; TISSUE

DOI:

10.1098/rsta.2006.1777

Web of Science ID:

ISI:000237920000004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN 15
Publisher	ROYAL SOCIETY
Address	6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
Language	English
Keywords-Plus	CARDIAC-MUSCLE; HETEROGENEOUS MYOCARDIUM; LEFT-VENTRICLE; MODELS; HEART; TISSUE
Research-Areas	Science \& Technology - Other Topics
Web-of-Science-Categories	Multidisciplinary Sciences
Author-Email	o.solovyova@iip.uran.ru
ResearcherID-Numbers	Lookin, Oleg/H-7454-2014 Konovalov, Pavel/D-9838-2015 Protsenko, Yuri/G-7185-2016 Balakina-Vikulova, Nathalie/D-9833-2015 Solovyova, Olga/T-8232-2017
ORCID-Numbers	Lookin, Oleg/0000-0001-9544-1885 Protsenko, Yuri/0000-0002-4693-244X Balakina-Vikulova, Nathalie/0000-0003-1316-4437 Kohl, Peter/0000-0003-0416-6270
Funding-Acknowledgement	FIC NIH HHS {[}1 R03 TW006250-01A1]; Wellcome Trust {[}074152]
Number-of-Cited-References	32
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	14
Journal-ISO	Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci.
Doc-Delivery-Number	048AO