Hybrid duplex: a novel method to study the contractile function of heterogeneous myocardium / Protsenko YL,Routkevitch SM,Gur'ev VY,Katsnelson LB,Solovyova O,Lookin ON,Balakin AA,Kohl P,Markhasin VS // AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. - 2005. - V. 289, l. 6. - P. H2733-H2746.

ISSN/EISSN:

0363-6135 / нет данных

Type:

Article

Abstract:

Hybrid duplex: a novel method to study the contractile function of heterogeneous myocardium. Am J Physiol Heart Circ Physiol 289: H2733-H2746, 2005. First published July 22, 2005; doi:10.1152/ajpheart. 00306.2005. -In an earlier study, we experimentally mimicked the effects of mechanical interaction between different regions of the ventricular wall by allowing pairs of independently maintained cardiac muscle fibers to interact mechanically in series or in parallel. This simple physiological model of heterogeneous myocardium, which has been termed ``duplex,{''} has provided new insight into basic effects of cardiac electromechanical heterogeneity. Here, we present a novel `` hybrid duplex,{''} where one of the elements is an isolated cardiac muscle and the other a `` virtual cardiac muscle.{''} The virtual muscle is represented by a computational model of cardiomyocyte electromechanical activity. We present in detail the computer-based digital control system that governs the mechanical interaction between virtual and biological muscle, the software used for data analysis, and working implementations of the model. Advantages of the hybrid duplex method are discussed, and experimental recordings are presented for illustration and as proof of the principle.

Author keywords:

heart muscle; muscle mechanics; mathematical model; real-time control; stretch HUMAN LEFT-VENTRICLE; CARDIAC-MUSCLE; TRANSMURAL HETEROGENEITY; ELECTRICAL HETEROGENEITY; MECHANICAL INHOMOGENEITY; INTRACELLULAR CALCIUM; REGIONAL ISCHEMIA; GENE-EXPRESSION; HUMAN HEART; I-KS

DOI:

10.1152/ajpheart.00306.2005

Web of Science ID:

ISI:000233176600060

Соавторы в МНС:

Другие поля

Поле	Значение
Month	DEC
Publisher	AMER PHYSIOLOGICAL SOC
Address	9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
Language	English
Keywords-Plus	HUMAN LEFT-VENTRICLE; CARDIAC-MUSCLE; TRANSMURAL HETEROGENEITY; ELECTRICAL HETEROGENEITY; MECHANICAL INHOMOGENEITY; INTRACELLULAR CALCIUM; REGIONAL ISCHEMIA; GENE-EXPRESSION; HUMAN HEART; I-KS
Research-Areas	Cardiovascular System \& Cardiology; Physiology
Web-of-Science-Categories	Cardiac \& Cardiovascular Systems; Physiology; Peripheral Vascular Disease
Author-Email	ylp@efif.uran.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017 Lookin, Oleg/H-7454-2014 Balakin, Alexander/D-5585-2014 Protsenko, Yuri/G-7185-2016
ORCID-Numbers	Lookin, Oleg/0000-0001-9544-1885 Protsenko, Yuri/0000-0002-4693-244X Kohl, Peter/0000-0003-0416-6270 Balakin, Alexander/0000-0002-7712-6686
Number-of-Cited-References	50
Usage-Count-Since-2013	12
Journal-ISO	Am. J. Physiol.-Heart Circul. Physiol.
Doc-Delivery-Number	982QL