Electron-conformational model of ryanodine receptor lattice dynamics / Moskvin AS,Philiplev MP,Solovyova OE,Kohl P,Markhasin VS // PROGRESS IN BIOPHYSICS \& MOLECULAR BIOLOGY. - 2006. - V. 90, l. 1-3. - P. 88-103.

ISSN/EISSN:

0079-6107 / нет данных

Type:

Article; Proceedings Paper

Abstract:

We propose a simple, physically reasonable electron-conformational model for the ryanodine receptor (RyR) and, on that basis, present a theory to describe RyR lattice responses to L-type channel triggering as an induced non-equilibrium phase transition. Each RyR is modelled with a single open and a single closed (electronic) state only, described utilizing a s = 1/2 pseudospin approach. In addition to the fast electronic degree of freedom, the RyR channel is characterized by a slow classical conformational coordinate, Q, which specifies the RyR channel calcium conductance and provides a multimodal continuum of possible RyR states. The cooperativity in the RyR lattice is assumed to be determined by inter-channel conformational coupling. Given a threshold sarcoplasmic reticulum (SR) calcium load, the RyR lattice fires due to a nucleation process with a step-by-step domino-like opening of a fraction of lattice channels, providing for a sufficient release to generate calcium sparks. The optimal mode of RyR lattice functioning during calcium-induced calcium release implies a fractional release with a robust termination due to a decrease in SR calcium load, accompanied by a respective change in effective conformational strain of the lattice. SR calcium overload is shown to result in excitation of RyR lattice auto-oscillations with spontaneous RyR channel opening and closure. (c) 2005 Elsevier Ltd. All rights reserved.

Author keywords:

calcium-induced calcium release; ryanodine receptor/channel; electron-conformational coupling; auto-oscillation INDUCED CALCIUM-RELEASE; SARCOPLASMIC-RETICULUM; CARDIAC-MUSCLE; LOCAL-CONTROL; CA2+; ACTIVATION

DOI:

10.1016/j.pbiomolbio.2005.06.0

Web of Science ID:

ISI:000234900400007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN-APR
Note	Integrative Physiology Workshop, Montpellier, FRANCE, SEP 03-05, 2004
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Keywords-Plus	INDUCED CALCIUM-RELEASE; SARCOPLASMIC-RETICULUM; CARDIAC-MUSCLE; LOCAL-CONTROL; CA2+; ACTIVATION
Research-Areas	Biochemistry \& Molecular Biology; Biophysics
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Biophysics
Author-Email	alexandr.moskvin@usu.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017
ORCID-Numbers	Kohl, Peter/0000-0003-0416-6270
Funding-Acknowledgement	Wellcome Trust
Number-of-Cited-References	17
Journal-ISO	Prog. Biophys. Mol. Biol.
Doc-Delivery-Number	006MA