Biophysical adaptation of the theory of photo-induced phase transition: model of cooperative gating of cardiac ryanodine receptors / Moskvin AS,Philipiev MP,Solovyova E,Markhasin VS // . - 2005. - V. 21, l. . - P. 195-200.

ISSN/EISSN:

1742-6588 / нет данных

Type:

Proceedings Paper

Abstract:

Theory of photo-induced phase transitions has been adapted to describe the cooperative dynamics of the lattice of ryanodine receptors/channels (RyR) in cardiac muscle which regulate the release of the intracellular activator calcium from calcium stores in the sarcoplasmic reticulum (SR) by a process of Ca2+-induced Ca2+ release (CICR). We introduce two main degrees of freedom for RyR channel, fast electronic and slow conformational ones. The RyR lattice response to the L-type channel triggering evolves due to a nucleation process with a step-by-step domino-like opening of RyR channels. Typical mode of RyR lattice functioning in a CICR process implies the fractional release with a robust termination due to the depletion of SR with a respective change in effective conformational strain. The SR overload leads to an unconventional auto-oscillation regime with a spontaneous calcium release. The model is believed to consistently describe the main features of CICR, that is its gradedness, coupled gating, irreversibility, inactivation/adaptation, and spark termination.

Author keywords:

INDUCED CALCIUM-RELEASE

DOI:

10.1088/1742-6596/21/1/032

Web of Science ID:

ISI:000233012100032

Соавторы в МНС:

Другие поля

Поле	Значение
Editor	Buron, M and Collet, E
Booktitle	Second International Conference on Photo-Induced Phase Transitions: Cooperative, Nonlinear and Functional Properties
Series	JOURNAL OF PHYSICS CONFERENCE SERIES
Note	2nd International Conference on Photo-Induced Phase Transitions, Univ Rennes 1, Rennes, FRANCE, MAY 24-28, 2005
Publisher	IOP PUBLISHING LTD
Address	DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
Language	English
Keywords-Plus	INDUCED CALCIUM-RELEASE
Research-Areas	Optics
Web-of-Science-Categories	Optics
Number-of-Cited-References	6
Doc-Delivery-Number	BDE32