Model of active transport of ions in cardiac cell / Melkikh A. V.,Sutormina M. I. // JOURNAL OF THEORETICAL BIOLOGY. - 2008. - V. 252, l. 2. - P. 247-254.

ISSN/EISSN:

0022-5193 / нет данных

Type:

Article

Abstract:

A model of the active transport of ions in a cardiac muscle cell, which takes into account the active transport of Na+, K+, Ca2+, Mg2+, HCO3- and Cl- ions, has been constructed. The model allows independent calculations of the resting potential at the biomembrane and concentrations of basic ions (sodium, potassium, chlorine, magnesium and calcium) in a cell. For the analysis of transport processes in cardiac cell hierarchical algorithm ``one ion-one transport system{''} was offered. The dependence of the resting potential on concentrations of the ions outside a cell has been established. It was shown, that ions of calcium and magnesium, despite their rather small concentration, play an essential role in maintenance of resting potential in cardiac cell. The calculated internal concentrations of ions are in good agreement with the corresponding experimental values. (C) 2008 Elsevier Ltd. All rights reserved.

Author keywords:

active transport of calcium and magnesium; Ca2+-Na+ and Mg2+-Na+ exchangers; resting potential; intracellular Ca2+ and Mg2+ concentrations; active transport of bicarbonate ions MAGNESIUM HOMEOSTASIS; BIOMEMBRANES; ROBUSTNESS; CALCIUM; HEART; PUMP; ATP

DOI:

10.1016/j.jtbi.2008.02.006

Web of Science ID:

ISI:000256237700006

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY 21
Publisher	ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Address	24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
Language	English
Keywords-Plus	MAGNESIUM HOMEOSTASIS; BIOMEMBRANES; ROBUSTNESS; CALCIUM; HEART; PUMP; ATP
Research-Areas	Life Sciences \& Biomedicine - Other Topics; Mathematical \& Computational Biology
Web-of-Science-Categories	Biology; Mathematical \& Computational Biology
Author-Email	mav@dpt.ustu.ru
Number-of-Cited-References	22
Usage-Count-Last-180-days	4
Usage-Count-Since-2013	9
Journal-ISO	J. Theor. Biol.
Doc-Delivery-Number	306HA