Nonequilibrium statistical model of active transport of ions and ATP production in mitochondria / Melkikh Alexey V.,Seleznev Vladimir D. // JOURNAL OF BIOLOGICAL PHYSICS. - 2007. - V. 33, l. 2. - P. 161-170.

ISSN/EISSN:

0092-0606 / нет данных

Type:

Article

Abstract:

A model of the active transport of ions through internal membranes of mitochondria is proposed. If concentrations of ions in a cell are known, this model allows calculating concentrations of all main ions (H+, Ca+2, K+, Mg2+, Na+, Cl-) in the mitochondrion matrix and the resting potential across the membrane. The theoretical values satisfactorily agree with available experimental data on the concentrations and the potentials, including different operating regimes of the adenosine triphosphate (ATP) synthetase (the main regime, short circuiting or ATP synthetase blocking). The active transport of Mg2+ ions in exchange for protons was assumed. In accordance with the model, the ATP synthetase operation is possible only if the stoichiometric coefficient of protons is 3.

Author keywords:

active transport of ions; mitochondria; ATP production; resting potential; mathematical model PERMEABILITY TRANSITION; HOMEOSTASIS; CA2+; BIOMEMBRANES; ROBUSTNESS; RELEASE

DOI:

10.1007/s10867-007-9053-0

Web of Science ID:

ISI:000253682200006

Соавторы в МНС:

Другие поля

Поле	Значение
Month	APR
Publisher	SPRINGER
Address	VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
Language	English
Keywords-Plus	PERMEABILITY TRANSITION; HOMEOSTASIS; CA2+; BIOMEMBRANES; ROBUSTNESS; RELEASE
Research-Areas	Biophysics
Web-of-Science-Categories	Biophysics
Author-Email	mav@dpt.ustu.ru
Number-of-Cited-References	21
Usage-Count-Since-2013	6
Journal-ISO	J. Biol. Phys.
Doc-Delivery-Number	269WT