Model of active transport of ions in biomembranes based on ATP-dependent change of height of diffusion barriers to ions / Melkikh Alexey V.,Seleznev Vladimir D. // JOURNAL OF THEORETICAL BIOLOGY. - 2006. - V. 242, l. 3. - P. 617-626.

ISSN/EISSN:

0022-5193 / нет данных

Type:

Article

Abstract:

A closed model of the active transport was constructed taking into account ATP-dependent opening and closing of barriers to ions and the relationship between the membrane potential and the work of ionic pumps under the condition of electroneutrality inside the cell. The internal consistency of the model was verified by the fulfillment of Onsager's reciprocity relation. It was demonstrated that at the limit of large energy barriers the operation of the system of the active transport is equivalent to the ``turning segment{''} model, which was proposed by the authors earlier. Values of the resting potential and the intracellular concentration of ions were obtained for different types of cells. These results were in qualitative agreement with relevant experimental data. (c) 2006 Elsevier Ltd. All rights reserved.

Author keywords:

height of diffusion barrier; active transport of ions; ATP-ase; resting potential POTENTIAL EQUATIONS; VOLTAGE-DEPENDENCE; CARDIAC MYOCYTES; PUMP; MOTORS

DOI:

10.1016/j.jtbi.2006.04.011

Web of Science ID:

ISI:000240947400009

Соавторы в МНС:

Другие поля

Поле	Значение
Month	OCT 7
Publisher	ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Address	24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
Language	English
Keywords-Plus	POTENTIAL EQUATIONS; VOLTAGE-DEPENDENCE; CARDIAC MYOCYTES; PUMP; MOTORS
Research-Areas	Life Sciences \& Biomedicine - Other Topics; Mathematical \& Computational Biology
Web-of-Science-Categories	Biology; Mathematical \& Computational Biology
Author-Email	mav@dpt.ustu.ru
Number-of-Cited-References	25
Usage-Count-Since-2013	1
Journal-ISO	J. Theor. Biol.
Doc-Delivery-Number	090JN