Models of active transport of ions in biomembranes of various types of cells / Melkikh AV,Seleznev VD // JOURNAL OF THEORETICAL BIOLOGY. - 2005. - V. 234, l. 3. - P. 403-412.

ISSN/EISSN:

0022-5193 / нет данных

Type:

Article

Abstract:

Nonequilibrium statistical models of the active transport of ions in biomembranes have been constructed. Differences of chemical potentials of the ATP-ADP reaction and the electrochemical potential of ions were taken as the thermodynamic forces responsible for the flow of ions through the membrane. The active transport of ions was viewed as a cross phenomenon arising from the chemical reaction of the ATP hydrolysis. These models provide independent calculations of the resting potential at the biomembrane and concentrations of ions in a cell on the assumption the free energy of the ATP-ADP reaction is fully (without the dissipation loss) converted to the free energy of transported ions. They take into account the presence of nonpenetrating ions in a cell. It was shown that different concentrations of nonpenetrating ions have a considerable effect on the resting potential. The proposed models were compared with experimental data obtained for different types of cells including neurons, muscular cells, bacteria, plants, and mitochondria. Calculated values of the membrane potential and ion concentrations were in good qualitative agreement with experimental data. (c) 2005 Elsevier Ltd. All rights reserved.

Author keywords:

active transport of ions; resting potential; nonpenetrating ions MOTORS

DOI:

10.1016/j.jtbi.2004.12.002

Web of Science ID:

ISI:000228221400009

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN 7
Publisher	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Address	24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
Language	English
Keywords-Plus	MOTORS
Research-Areas	Life Sciences \& Biomedicine - Other Topics; Mathematical \& Computational Biology
Web-of-Science-Categories	Biology; Mathematical \& Computational Biology
Author-Email	mav@dpt.ustu.ru
Number-of-Cited-References	19
Usage-Count-Since-2013	2
Journal-ISO	J. Theor. Biol.
Doc-Delivery-Number	914IP