Synthesis of 4-oxothiazolidine-2,5-diylidenes containing thioamide group based on dithiomalonamides / Obydennov K. L.,Golovko N. A.,Kosterina M. F.,Pospelova T. A.,Slepukhin P. A.,Morzherin Yu. Yu. // RUSSIAN CHEMICAL BULLETIN. - 2014. - V. 63, l. 6. - P. 1330-1336.

ISSN/EISSN:

1066-5285 / 1573-9171

Type:

Article

Abstract:

An approach to the synthesis of 2-(4-oxo-3-arylthiazolidine-2,5-diylidene)-N-arylethanethioamide derivatives from N,N'-diarylmalonodithioamides includes two steps: preparation of thiazoles using the Hantzsch reaction with subsequent modification of the active methylene group by the Knoevenagel condensation or enamination using dimethylformamide dimethyl acetal (DMF-DMA). Configuration and isomerization of the double bonds in 4-oxothiazolidine2,5-diylidenes were confirmed by H-1 NMR and X-ray diffraction analysis and discussed.

Author keywords:

thiazolidin-4-one; 4-oxothiazole; thioamide; isatin; rhodacyanine; DMF-DMA; malonodithioamide ADAMTS-5 AGGRECANASE-2 INHIBITORS; BIOLOGICAL EVALUATION; DERIVATIVES BEARING; SERIES; 4-THIAZOLIDINONE; REACTIVITY; SCAFFOLD; DESIGN; MOIETY

DOI:

нет данных

Web of Science ID:

ISI:000350877500011

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9171
Keywords-Plus	ADAMTS-5 AGGRECANASE-2 INHIBITORS; BIOLOGICAL EVALUATION; DERIVATIVES BEARING; SERIES; 4-THIAZOLIDINONE; REACTIVITY; SCAFFOLD; DESIGN; MOIETY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	yu.yu.morzherin@urfu.ru
ResearcherID-Numbers	Obydennov, Konstantin/M-7550-2013 Morzherin, Yury/M-7420-2013
ORCID-Numbers	Obydennov, Konstantin/0000-0002-5884-4105 Morzherin, Yury/0000-0002-1333-6676
Number-of-Cited-References	31
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	11
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	CD2BC