Synthesis of Pyrimido{[}2,1-b]{[}1,3,5]Thiadiazines Containing Polyfluoroalkyl- and Amino Acid Fragments / Khudina O. G.,Ivanova A. E.,Burgart Ya. V.,Saloutin V. I. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2014. - V. 50, l. 6. - P. 901-906.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

8-Polyfluoroalkylpyrimido{[}2,1-b]{[}1,3,5]thiadiazine-6-ones containing a structural fragment of amino acid or its ester were synthesized by a multicomponent cyclization of 6-polyfluoroalkyl-2-thiouracils with formaldehyde and amines. The use of diamino acids allowed the preparation of bis(pyrimido-{[}2,1-b]{[}1,3,5]thiadiazin-6-ones), containing an aliphatic linker with a carboxy group. Two of the synthesized compounds exhibited weak antituberculosis activity in vitro.

Author keywords:

amino acids; formaldehyde; pyrimido{[}2,1-b]thiadiazines; 6-polyfluoroalkyl-2-thiouracils; Mannich reaction; tuberculostatic activity MANNICH REACTION; DERIVATIVES

DOI:

10.1007/s10593-014-1544-x

Web of Science ID:

ISI:000340878300012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	MANNICH REACTION; DERIVATIVES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	burgart@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement	Russian Foundation for Basic Research {[}13-03-00617]; Program of Ural Branch of the Russian Academy of Sciences {[}12-M-34-2064]; Grants Council of the President of the Russian Federation {[}NSh-3656.2014.3]
Funding-Text	The work was performed with financial support from the Russian Foundation for Basic Research (grant 13-03-00617), the Program of Ural Branch of the Russian Academy of Sciences (project 12-M-34-2064), and the Grants Council of the President of the Russian Federation (grant NSh-3656.2014.3).
Number-of-Cited-References	11
Usage-Count-Since-2013	2
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	AN8TV