Synthesis and Antibacterial Activity of N-Alkyl-Substituted 4-Aryldiazenylpyrazoles / Ivanova A. E.,Burgart Ya. V.,Saloutin V. I. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2013. - V. 49, l. 8. - P. 1128-1135.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

Alkylation of 4-aryldiazenylpyrazoles using (4-bromobutyl)acetate and {[}(2-acetoxyethoxy)methyl]-acetate gave the corresponding 1-(4-acetoxybutyl)- and 1-{[}(2-acetoxyethoxy)methyl]pyrazoles. 3-Fluoroalkyl-4-aryldiazenylpyrazoles react with (4-bromobutyl)acetate to form a mixture of the regio-isomeric 1-(4-acetoxybutyl)-3- and 1-(4-acetoxybutyl)-5-fluoroalkylpyrazoles. Several of the acetoxy- pyrazole derivatives were deacylated and isolated using HPLC. Modest activity towards the ATCC 6633 strain of bacteria Bacillus subtilis has been found for 1-(4-hydroxybutyl)-5-methyl-4-{[}(4-methyl-phenyl)diazenyl]-3-(octafluor obutyl)-1H-pyrazole.

Author keywords:

pyrazoles; regioisomers; alkylation; deacylation; tuberculostatic and antibacterial activity 1,2,3-TRIKETONES; NUCLEOSIDES; INHIBITORS; PYRAZOLES; ANALOGS

DOI:

10.1007/s10593-013-1353-7

Web of Science ID:

ISI:000326375500004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	1,2,3-TRIKETONES; NUCLEOSIDES; INHIBITORS; PYRAZOLES; ANALOGS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	ivanova@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement	Ural Branch of the Russian Academy of Sciences {[}12-P-3-1030, 13-3-NP-536]; grant of the President Council of the Russian Federation {[}MK-837.2012.3]; Russian Foundation for Basic Research {[}13-03-00617]
Funding-Text	This work was carried out with the financial support of the Ural Branch of the Russian Academy of Sciences (projects 12-P-3-1030 (Russian Academy of Sciences Presidium Program ``Basic Sciences - Medicine{''}), and 13-3-NP-536), grant of the President Council of the Russian Federation (MK-837.2012.3), and the Russian Foundation for Basic Research (grant 13-03-00617).
Number-of-Cited-References	21
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	3
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	244GN