Modification of 2-trifluoromethyl-1H-benzimidazole with hydroxyalkyl substituents / Shchegol'kov E. V.,Ivanova A. E.,Burgart Ya. V.,Saloutin V. I.,Chupakhin O. N. // RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. - 2013. - V. 49, l. 3. - P. 417-420.

ISSN/EISSN:

1070-4280 / нет данных

Type:

Article

Abstract:

Alkylation of 2-(trifluoromethyl)-1H-benzimidazole with 4-bromobutyl acetate gave 4-{[}2-(trifluoromethyl)-1H-benzimidazol-1-yl]butyl acetate which was deacylated by the action of hydrogen chloride in anhydrous ethanol. 4-{[}2-(Trifluoromethyl)-1H-benzimidazol-1-yl]butan-1-ol thus formed showed a moderate tuberculostatic activity. Alkylation of the title compound with chloromethyloxirane afforded a mixture of 1-chloro-3-{[}2-(trifluoromethyl)-1H-benzimidazol-1-yl]-propan-2-ol and 1-(oxiran-2-ylmethyl)-2-trifluoromethyl-1H-benzimidazole. A new procedure was proposed for the synthesis of 2-{[}(2-trifluoromethyl-1Hbenzimidazol-1-yl)methoxy]ethyl acetate.

Author keywords:

DERIVATIVES; ANALOGS

DOI:

10.1134/S1070428013030172

Web of Science ID:

ISI:000317353500017

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
Keywords-Plus	DERIVATIVES; ANALOGS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	ivanova@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017 Shchegol'kov, Evgenii/H-6790-2015
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410 Shchegol'kov, Evgenii/0000-0001-6611-2855
Funding-Acknowledgement	Ural Branch of the Russian Academy of Sciences (program of the Presidium of the Russian Academy of Sciences ``Fundamental Sciences for Medicine,{''} ) {[}12-P-3-1030]; Council for Grants at the President of the Russian Federation {[}MK-837.2012.3]
Funding-Text	This study was performed under financial support by the Ural Branch of the Russian Academy of Sciences (program of the Presidium of the Russian Academy of Sciences ``Fundamental Sciences for Medicine,{''} project no. 12-P-3-1030) and by the Council for Grants at the President of the Russian Federation (project no. MK-837.2012.3).
Number-of-Cited-References	7
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	5
Journal-ISO	Russ. J. Organ. Chem.
Doc-Delivery-Number	122YC