Features of synthesis and structure of ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)-propyl-2-enoate / Bazhin D. N.,Shchegol'kov E. V.,Kudyakova Yu. S.,Scherbakov K. V.,Burgart Ya. V.,Saloutin V. I. // RUSSIAN JOURNAL OF GENERAL CHEMISTRY. - 2012. - V. 82, l. 1. - P. 116-121.

ISSN/EISSN:

1070-3632 / нет данных

Type:

Article

Abstract:

The structure of key intermediates in the synthesis of fluoroquinolone antibiotics: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate and ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)prop-2-enoate was for first time studied using X-ray diffraction (XRD) and H-1, F-19 NMR spectroscopy. In solution both the esters were shown to exist as a mixture of enol and ketone tautomeric forms with predominance of the latter. According to the XRD analysis, ethyl (2Z)-3-hydroxy-(2,3,4,5-tetrafluorophenyl)prop-2-enoate in the solid state exists entirely in the enol form.

Author keywords:

ANTIBACTERIAL AGENTS; DERIVATIVES; OFLOXACIN; ANALOGS; ESTERS; ACIDS

DOI:

10.1134/S1070363212010197

Web of Science ID:

ISI:000300454700019

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
Keywords-Plus	ANTIBACTERIAL AGENTS; DERIVATIVES; OFLOXACIN; ANALOGS; ESTERS; ACIDS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	bazhin@ios.uran.ru
ResearcherID-Numbers	Kudyakova, Yulia/J-7484-2016 Shchegol'kov, Evgenii/H-6790-2015 Bazhin, Denis/G-1933-2011 Burgart, Yanina/T-8025-2017 Bazhin, Denis/P-4667-2014
ORCID-Numbers	Kudyakova, Yulia/0000-0003-0637-1606 Shchegol'kov, Evgenii/0000-0001-6611-2855 Burgart, Yanina/0000-0001-6061-2410 Bazhin, Denis/0000-0003-3972-6995
Funding-Acknowledgement	State Contract {[}02.522.12.2011]
Funding-Text	This work was performed along the State Contract no. 02.522.12.2011.
Number-of-Cited-References	22
Usage-Count-Since-2013	2
Journal-ISO	Russ. J. Gen. Chem.
Doc-Delivery-Number	894VF