Synthesis of polyfluoroalkyl-containing 1-(4-acetoxybutyl)- and 1-(4-hydroxybutyl)pyrazoles and their tuberculostatic activity / Ivanova A. E.,Khudina O. G.,Burgart Ya. V.,Saloutin V. I.,Kravchenko M. A. // RUSSIAN CHEMICAL BULLETIN. - 2011. - V. 60, l. 11. - P. 2396-2400.

ISSN/EISSN:
1066-5285 / нет данных
Type:
Article
Abstract:
Alkylation of polyfluoroalkyl-containing pyrazoles with 4-bromobutyl acetate in acetone in the presence of potassium carbonate leads to a mixture of isomeric 1-(4-acetoxybutyl)-3-fluoroalkyl- and 1-(4-acetoxybutyl)-5-fluoroalkylpyrazoles, which in a number of cases were successfully separated by HPLC. Deacylation in acidic medium with gaseous hydrogen chloride and in basic medium with gaseous ammonia leads to 1-(4-hydroxybutyl)pyrazoles, which manifest moderate tuberculostatic activity.
Author keywords:
pyrazoles; alkylation; deacylation; tuberculostatic activity IDENTIFICATION
DOI:
10.1007/s11172-011-0368-4
Web of Science ID:
ISI:000307517100038
Соавторы в МНС:
Другие поля
Поле Значение
Month NOV
Publisher SPRINGER
Address 233 SPRING ST, NEW YORK, NY 10013 USA
Language English
Keywords-Plus IDENTIFICATION
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Multidisciplinary
Author-Email saloutin@ios.uran.ru kravchenko@nexcom.ru
ResearcherID-Numbers Burgart, Yanina/T-8025-2017
ORCID-Numbers Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement Russian Foundation for Basic Research {[}09-03-00274a]; Ministry of Education and Science of the Russian Federation {[}02.740.11.0260]; Ural Branch of the Russian Academy of Sciences {[}09-I-3-2004]; Counsil on Grants at the President (Program of State Support for Leading Scientific Schools of the Russian Federation) {[}NSh-65261.2010.3]
Funding-Text This work was financially supported by the Russian Foundation for Basic Research (Project No. 09-03-00274a), the Ministry of Education and Science of the Russian Federation (State Contract 02.740.11.0260), the Ural Branch of the Russian Academy of Sciences (Integration Project of Basic Research No. 09-I-3-2004), and the Counsil on Grants at the President (Program of State Support for Leading Scientific Schools of the Russian Federation, Grant NSh-65261.2010.3).
Number-of-Cited-References 8
Usage-Count-Since-2013 3
Journal-ISO Russ. Chem. Bull.
Doc-Delivery-Number 988UV