One-pot synthesis of 5-fluoroalkyl-5-hydroxy-4-hydroxy-imino-1-isonicotinoyl-4,5-dihydro-1H-p yrazoles and their tuberculostatic activity / Khudina O. G.,Burgart Ya. V.,Saloutin V. I.,Kravchenko M. A. // RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. - 2011. - V. 47, l. 6. - P. 904-909.

ISSN/EISSN:
1070-4280 / нет данных
Type:
Article
Abstract:
5-Fluoroalkyl-5-hydroxy-4-hydroxyimino-1-isonicotinoyl-4,5-dihydro-1H-py razoles were synthesized via a one-pot procedure from polyfluoroalkyl-containing 1,3-diketones, sodium nitrite in acetic acid, and isoniazid. Acetylacetone gave rise to 3-hydroxyiminopentane-2,4-dione monoisonicotinoylhydrazone which underwent intramolecular cyclization to 5-hydroxy-4-hydroxyimino-1-isonicotinoyl-3,5-dimethyl-4,5-dihydro-1H-pyr azole on heating in ethanol. The synthesized compounds exhibited moderate tuberculostatic activity.
Author keywords:
нет данных
DOI:
10.1134/S1070428011060121
Web of Science ID:
ISI:000292562900012
Соавторы в МНС:
Другие поля
Поле Значение
Month JUN
Publisher MAIK NAUKA/INTERPERIODICA/SPRINGER
Address 233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language English
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Organic
Author-Email saloutin@ios.uran.ru
ResearcherID-Numbers Burgart, Yanina/T-8025-2017
ORCID-Numbers Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement Russian Foundation for Basic Research {[}09-03-00274a]; Integration Project for Basic Research at the Ural Division of the Russian Academy of Sciences {[}09-I-3-2004]; State Support of Leading Scientific Schools {[}NSh-65261.2010.3]; {[}02.740.11.0260]
Funding-Text This study was performed under financial support by the Russian Foundation for Basic Research (project no. 09-03-00274a), by the state contract no. 02.740.11.0260, by the Integration Project for Basic Research at the Ural Division of the Russian Academy of Sciences ``Scientific Principles of the Design and Development of Medicines of Natural and Synthetic Origin{''} (project no. 09-I-3-2004), and by the Program for State Support of Leading Scientific Schools (project no. NSh-65261.2010.3).
Number-of-Cited-References 6
Usage-Count-Since-2013 5
Journal-ISO Russ. J. Organ. Chem.
Doc-Delivery-Number 790BG