Synthesis of regioisomeric N- and O-alkylated 3-polyfluoroalkyl-1,2-dihydroquinoxalin-2-ones / Ivanova A. E.,Khudina O. G.,Burgart Ya V.,Saloutin V. I. // RUSSIAN CHEMICAL BULLETIN. - 2011. - V. 60, l. 5. - P. 937-941.

ISSN/EISSN:
1066-5285 / нет данных
Type:
Article
Abstract:
3-Polyfluoroalkyl-1,2-dihydroquinoxalin-2-ones react with 4-bromobutyl acetate to furnish 1-(4-acetoxybutyl)quinoxalin-2-ones and 2-(4-acetoxybutoxy)quinoxalines in the ratio 2: 1. Deacylation of these compounds under acidic conditions gives the corresponding 1-(4-hydroxybutyl)- and 2-(4-hydroxybutoxy)-substituted quinoxalines. The structures of compounds synthesized were established by X-ray crystallography, IR spectroscopy, (1)H and (19)F NMR spectroscopy, GLC-MS.
Author keywords:
analogs of acyclic nucleosides; 3-polyfluoroalkylquinoxalin-2-ones; alkylation; regioisomers; deacylation ANTITUMOR AGENT; ANALOGS; 9-(2-HYDROXYETHOXYMETHYL)GUANINE
DOI:
10.1007/s11172-011-0147-2
Web of Science ID:
ISI:000297153800023
Соавторы в МНС:
Другие поля
Поле Значение
Month MAY
Publisher SPRINGER
Address 233 SPRING ST, NEW YORK, NY 10013 USA
Language English
Keywords-Plus ANTITUMOR AGENT; ANALOGS; 9-(2-HYDROXYETHOXYMETHYL)GUANINE
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Multidisciplinary
Author-Email saloutin@ios.uran.ru
ResearcherID-Numbers Burgart, Yanina/T-8025-2017
ORCID-Numbers Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement Russian Foundation for Basic Research {[}09-03-00274a]; Ministry of Education and Science of the Russian Federation {[}02.740.11.0260]; Ural Branch of the Russian Academy of Sciences {[}09-I-3-2004]; Council on Grants at the President of the Russian Federation {[}NSh-65261.2010.3]
Funding-Text This work was financially supported by the Russian Foundation for Basic Research (Project No. 09-03-00274a), the Ministry of Education and Science of the Russian Federation (State Contract No. 02.740.11.0260), the Ural Branch of the Russian Academy of Sciences (Integration Project for Basic Research No. 09-I-3-2004), and the Council on Grants at the President of the Russian Federation (Program of State Support for Leading Scientific Schools of the RF, Grant NSh-65261.2010.3).
Number-of-Cited-References 17
Usage-Count-Since-2013 4
Journal-ISO Russ. Chem. Bull.
Doc-Delivery-Number 849VQ